iPTMnet Report for Q15393 (SF3B3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15393 / SF3B3_HUMAN
Protein Name Splicing factor 3B subunit 3
Gene Name Name: SF3B3
Synonyms:KIAA0017,SAP130;
Organism Homo sapiens (Human)

PRO ID PR:Q15393
DAG View
PRO Name splicing factor 3B subunit 3 (human)
Definition A splicing factor 3B subunit 3 that is encoded in the genome of human.
Short Label hSF3B3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15393 (SF3B3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K26 Ubiquitination PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
T71 Phosphorylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
Y77 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K109 Acetylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K126 Acetylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
S133 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...32522876, 34725712, 28510447, 29351928, 34019948, 35083852, 32119511, 30620550, 22121020
S133 Phosphorylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
T153 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus   UniProt 23186163
T237 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...32522876, 34725712, 28510447, 29351928, 34019948, 35083852, 32119511, 30620550, 22121020
R268 Methylation PhosphoSitePlus
T314 Phosphorylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
S477 Phosphorylation IEDB 32387766
K537 Ubiquitination PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
S696 Phosphorylation PhosphoSitePlus
K700 Ubiquitination PhosphoSitePlus
K769 Ubiquitination PhosphoSitePlus
T784 Phosphorylation PhosphoSitePlus
K787 Acetylation PhosphoSitePlus
K787 Ubiquitination PhosphoSitePlus
Y807 Phosphorylation PhosphoSitePlus
K812 Ubiquitination PhosphoSitePlus
K816 Ubiquitination PhosphoSitePlus
C894 Methylation IEDB 31844290
Y904 Phosphorylation PhosphoSitePlus
Y926 Phosphorylation PhosphoSitePlus
K936 Ubiquitination PhosphoSitePlus
K942 Ubiquitination PhosphoSitePlus
K965 Ubiquitination PhosphoSitePlus
R968 Methylation PhosphoSitePlus
K974 Ubiquitination PhosphoSitePlus
Y989 Phosphorylation PhosphoSitePlus
Y1029 Phosphorylation PhosphoSitePlus
Y1041 Phosphorylation PhosphoSitePlus
T1043 Phosphorylation PhosphoSitePlus
K1049 Ubiquitination PhosphoSitePlus
K1074 Ubiquitination PhosphoSitePlus
R1079 Methylation PhosphoSitePlus
K1088 Ubiquitination PhosphoSitePlus
R1164 Methylation PhosphoSitePlus
K1171 Ubiquitination PhosphoSitePlus
K1189 Ubiquitination PhosphoSitePlus
K1191 Ubiquitination PhosphoSitePlus
S1194 Phosphorylation PhosphoSitePlus
T1200 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1206 Acetylation PhosphoSitePlus
K1206 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S133 Phosphorylation HPRD 20068231
T1200 Phosphorylation HPRD 20068231, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T71 I71 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R268 H268 Biomuta DOID:1324 / lung cancer [ cosmic ]
R268 C268 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
K787 T787 Biomuta DOID:363 / uterine cancer [ icgc ]
K1049 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
R1079 S1079 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R1164 H1164 Biomuta DOID:363 / uterine cancer [ icgc ]
R1164 C1164 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K1171 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K1171 N1171 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1189 T1189 Biomuta DOID:9256 / colorectal cancer [ icgc ]