iPTMnet Report for Q15257 (PTPA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15257 / PTPA_HUMAN
Protein Name Serine/threonine-protein phosphatase 2A activator
Gene Name Name: PTPA
Synonyms:PPP2R4;
Organism Homo sapiens (Human)

PRO ID PR:Q15257
DAG View
PRO Name serine/threonine-protein phosphatase 2A activator (human)
Definition A serine/threonine-protein phosphatase 2A regulatory subunit B' that is encoded in the genome of human.
Short Label hPTPA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15257 (PTPA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
K27 Ubiquitination PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
K62 Acetylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
S88 Phosphorylation RLIMS-P 28613156
S90 Phosphorylation PhosphoSitePlus
T118 Phosphorylation PhosphoSitePlus
R121 Methylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
R141 Methylation PhosphoSitePlus
Y223 Phosphorylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K321 Acetylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
K331 Acetylation PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K337 Acetylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K345 Acetylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
S357 O-Glycosylation GlyGen 34019948, 28657654
S357 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T126 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T91 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P30305 (CDC25B) S353 Q15257 (PTPA) unknown eFIP 33385163
Phosphorylation P35222 (CTNNB1) S675 Q15257 (PTPA) increased_association eFIP 28700668
Phosphorylation P56211 (ARPP19) S46 Q15257 (PTPA) inhibited_association eFIP 28613156
Phosphorylation Q16566 (CAMK4) T200 Q15257 (PTPA) unknown eFIP 15143065
Phosphorylation Q6NZ36 (FAAP20) S48 Q15257 (PTPA) decreased_association eFIP 30789902
Phosphorylation Q6UUV7 (CRTC3) S391 Q15257 (PTPA) increased_association eFIP 30611118


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T118 M118 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ]
R121 M121 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y223 C223 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K345 R345 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S357 L357 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ]