iPTMnet Report for Q15208 (STK38)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15208 / STK38_HUMAN
Protein Name Serine/threonine-protein kinase 38
Gene Name Name: STK38
Synonyms:NDR1;
Organism Homo sapiens (Human)

PRO ID PR:Q15208
DAG View
PRO Name serine/threonine-protein kinase 38 (human)
Definition A serine/threonine-protein kinase 38 that is encoded in the genome of human.
Short Label hSTK38
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15208 (STK38) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T4 Phosphorylation PhosphoSitePlus
S6 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P 22142472
T7 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P 22142472
S10 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   RLIMS-P 22142472
S11 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 22142472
S13 Phosphorylation PhosphoSitePlus
T16 Phosphorylation PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
T26 Phosphorylation PhosphoSitePlus
Y31 Phosphorylation PhosphoSitePlus
K58 Acetylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
T74 Phosphorylation Q15208 (STK38) HPRD   PhosphoSitePlus   RLIMS-P   Signor   UniProt 31690749, 12493777
S91 Phosphorylation PhosphoSitePlus   RLIMS-P 31690749
K93 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
T183 Phosphorylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
C234 S-Nitrosylation dbSNO 22178444
T235 Phosphorylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
T243 Phosphorylation PhosphoSitePlus   RLIMS-P 31690749
S252 Phosphorylation PhosphoSitePlus
S264 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
K265 Ubiquitination PhosphoSitePlus
T270 Phosphorylation PhosphoSitePlus   RLIMS-P 31690749
S281 Phosphorylation Q15208 (STK38) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15067004, 10567341, 28322254, ...16314523, 12493777, 29983373, 16135814, 14661952
T282 Phosphorylation PhosphoSitePlus
T285 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y288 Phosphorylation PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
T407 Phosphorylation PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
Y443 Phosphorylation PhosphoSitePlus
T444 Phosphorylation P26927 (MST1) , Q15208 (STK38) , Q9Y6E0 (STK24) , Q13043 (STK4) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16314523, 12840024, 10567341, ...28322254, 16135814, 12493777, 26387716, 19062280, 19836237, 21730291, 27283898, 21262772
Y445 Phosphorylation PhosphoSitePlus
T452 Phosphorylation PhosphoSitePlus
R454 Methylation PhosphoSitePlus
Y460 Phosphorylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus


Q15208 (STK38) as PTM Enzyme



Substrate Site Score Source PMID
P38936 (CDKN1A) S146 neXtProt   Signor 21262772
P46937 (YAP1) S61 PhosphoSitePlus 25601544
P46937 (YAP1) S109 PhosphoSitePlus   Signor 25601544
P46937 (YAP1) S127 PhosphoSitePlus   Signor 25601544
P46937 (YAP1) S164 PhosphoSitePlus 25601544
Q02241 (KIF23) S716 PhosphoSitePlus 25658096
Q02241 (KIF23) S814 PhosphoSitePlus 25658096
Q15208 (STK38) T74 HPRD   Signor 12493777
Q15208 (STK38) S281 HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 15067004, 12493777, 16314523
Q15208 (STK38) T444 HPRD   PhosphoSitePlus   Signor 12493777
Q2M2I8 (AAK1) S637 neXtProt 22445341
Q96QF0 (RAB3IP) S288 neXtProt   PhosphoSitePlus 23435566, 22445341
Q96RD6 (PANX2) S514 neXtProt 22445341
Q9BXF6 (RAB11FIP5) S307 neXtProt 22445341
Q9UBF8 (PI4KB) S277 neXtProt 22445341


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9H8S9 (MOB1A) T12 Q15208 (STK38) unknown eFIP 27213455


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q15208 (hSTK38) Interaction PR:Q96GD4 (hAURKB) PRO 20171103
PR:Q96GD4 (hAURKB) Interaction PR:Q15208 (hSTK38) PRO 20171103


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T4 K4 Biomuta DOID:3571 / liver cancer [ cosmic ]
S6 P6 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S6 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T26 S26 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C234 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K354 N354 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T444 M444 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y445 H445 Biomuta DOID:4159 / skin cancer [ cosmic ]