iPTMnet Report for Q15181 (PPA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15181 / IPYR_HUMAN
Protein Name Inorganic pyrophosphatase
Gene Name Name: PPA1
Synonyms:IOPPP,PP;
Organism Homo sapiens (Human)

PRO ID PR:Q15181
DAG View
PRO Name inorganic pyrophosphatase (human)
Definition An inorganic pyrophosphatase that is encoded in the genome of human.
Short Label hPPA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15181 (PPA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22814378, 22223895
S2 Phosphorylation HPRD   PhosphoSitePlus 20068231
S5 Phosphorylation HPRD   PhosphoSitePlus 20068231
T6 Phosphorylation HPRD   PhosphoSitePlus 20068231
S14 Phosphorylation PhosphoSitePlus
Y17 Phosphorylation PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
K25 Acetylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
Y28 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
Y38 Phosphorylation PhosphoSitePlus
K57 Acetylation PhosphoSitePlus   UniProt 19608861
K63 Acetylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K70 Acetylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K74 Acetylation PhosphoSitePlus
K75 Acetylation PhosphoSitePlus
Y80 Phosphorylation PhosphoSitePlus
Y94 Phosphorylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
R132 Methylation PhosphoSitePlus
K155 Acetylation PhosphoSitePlus
K176 Acetylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
T186 Phosphorylation PhosphoSitePlus   RLIMS-P 27918433
Y193 Phosphorylation PhosphoSitePlus
K194 Acetylation PhosphoSitePlus
K199 Acetylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K228 Acetylation PhosphoSitePlus   UniProt 19608861
K228 Ubiquitination PhosphoSitePlus
T235 Phosphorylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
T246 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
S250 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
K253 Acetylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
C270 S-Nitrosylation dbSNO 26338901
C274 S-Nitrosylation dbSNO 26338901
K282 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O14974 (PPP1R12A) T696 Q15181 (PPA1) unknown eFIP 25980620


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K57 N57 Biomuta DOID:1612 / breast cancer [ cosmic ]
K75 * Biomuta DOID:4159 / skin cancer [ cosmic ]
R132 I132 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K179 * Biomuta DOID:4159 / skin cancer [ cosmic ]
T235 M235 Biomuta DOID:5041 / esophageal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
S248 Y248 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
C274 Y274 Biomuta DOID:4159 / skin cancer [ cosmic ]