iPTMnet Report for Q15172 (PPP2R5A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15172 / 2A5A_HUMAN
Protein Name Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Gene Name Name: PPP2R5A
Organism Homo sapiens (Human)

PRO ID PR:Q15172
DAG View
PRO Name serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (human)
Definition A serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform that is encoded in the genome of human.
Short Label hPPP2R5A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15172 (PPP2R5A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22223895
S5 Phosphorylation PhosphoSitePlus
S28 Phosphorylation P19525 (EIF2AK2) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10866685, 18957415
S38 Phosphorylation PhosphoSitePlus
S41 Phosphorylation P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 18669648, ...24225947, 20068231
S42 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
S46 Phosphorylation PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus   UniProt 23186163
K181 Acetylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
T421 Phosphorylation PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
Y474 Phosphorylation PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S28 Phosphorylation P19525 (EIF2AK2) HPRD 10866685
S41 Phosphorylation HPRD 18669648, 20068231
S42 Phosphorylation HPRD 18669648, 20068231
S472 Phosphorylation HPRD 20068231


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000035428 (hBUB1B/Phos:2) increased Interaction PR:Q15172 (hPPP2R5A) PRO 23079597
PR:Q15172 (hPPP2R5A) Interaction PR:000035428 (hBUB1B/Phos:2) PRO 23079597


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 L2 Biomuta DOID:4159 / skin cancer [ cosmic ]
K316 N316 Biomuta DOID:1612 / breast cancer [ cosmic ]
K457 Q457 Biomuta DOID:363 / uterine cancer [ icgc ]
S484 N484 Biomuta DOID:1612 / breast cancer [ cosmic ]
S484 R484 Biomuta DOID:10283 / prostate cancer [ icgc ]