iPTMnet Report for Q15126 (PMVK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15126 / PMVK_HUMAN
Protein Name Phosphomevalonate kinase
Gene Name Name: PMVK
Synonyms:PMKI;
Organism Homo sapiens (Human)

PRO ID PR:Q15126
DAG View
PRO Name phosphomevalonate kinase (human)
Definition A phosphomevalonate kinase that is encoded in the genome of human.
Short Label hPMVK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15126 (PMVK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation HPRD   PhosphoSitePlus 20068231
K17 Ubiquitination PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
T67 Phosphorylation PhosphoSitePlus
Y68 Phosphorylation HPRD 20068231
K69 Ubiquitination PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K22 N22 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K48 E48 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S66 I66 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y68 C68 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K94 T94 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S113 F113 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]