iPTMnet Report Q15119 PDK2

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q15119 / PDK2_HUMAN
Protein Name	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial precursor
Gene Name	Name: PDK2 Synonyms:PDHK2;
Organism	Homo sapiens (Human)

PRO ID	PR:Q15119 DAG View
PRO Name	[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (human)
Definition	A [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial that is encoded in the genome of human.
Short Label	hPDK2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q15119 (PDK2) as Substrate

Q15119

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T118	Phosphorylation		score1	PhosphoSitePlus
	S285	Phosphorylation		score1	PhosphoSitePlus
	R291	Methylation		score1	PhosphoSitePlus
	K376	Ubiquitination		score1	PhosphoSitePlus

Q15119 (PDK2) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	P08559 (PDHA1)	S232	score2	PhosphoSitePlus	11092882
	P08559 (PDHA1)	S293	score4	HPRD neXtProt PhosphoSitePlus	18691976, 22910903, 16436377, ...18767875, 11486000, 12676647, 20166139, 11092882, 11485553, 19415658, 18212344
	P08559 (PDHA1)	S300	score4	HPRD neXtProt PhosphoSitePlus Signor	18691976, 22910903, 16436377, ...11486000, 12676647, 17474719, 20166139, 11092882, 11485553, 19415658, 18212344
	P29803 (PDHA2)	S291	score3	neXtProt PhosphoSitePlus Signor	16436377
	P29803 (PDHA2)	S298	score2	PhosphoSitePlus	16436377

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
R291	*	Biomuta		DOID:4159 / skin cancer [ cosmic ]