iPTMnet Report for Q15084 (PDIA6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15084 / PDIA6_HUMAN
Protein Name Protein disulfide-isomerase A6 precursor
Gene Name Name: PDIA6
Synonyms:ERP5,P5,TXNDC7;
Organism Homo sapiens (Human)

PRO ID PR:Q15084
DAG View
PRO Name protein disulfide-isomerase A6 (human)
Definition A protein disulfide-isomerase A6 that is encoded in the genome of human.
Short Label hPDIA6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15084 (PDIA6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 9058200
K66 Methylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
K102 Acetylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
T119 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus   UniProt 24275569
R142 Methylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
S156 Phosphorylation UniProt 26091039
S158 Phosphorylation PhosphoSitePlus   UniProt 23186163
K160 Ubiquitination PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K216 Acetylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
T239 Phosphorylation PhosphoSitePlus
K241 Acetylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
Y252 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
Y316 Phosphorylation PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
R392 Methylation PhosphoSitePlus
R409 Methylation PhosphoSitePlus
S428 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16964243, 15302935, ...18318008, 18669648, 24275569, 9058200, 19690332, 20068231, 17081983
Site PTM Type PTM Enzyme Score Source PMID
S428 Phosphorylation HPRD 19413330, 18212344, 20058876, ...15302935, 18452278, 19651622, 18669648, 18707149, 20166139, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K102 N102 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K102 Q102 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R142 L142 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S315 Y315 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S377 C377 Biomuta DOID:9256 / colorectal cancer [ cosmic ]