iPTMnet Report for Q15059 (BRD3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15059 / BRD3_HUMAN
Protein Name Bromodomain-containing protein 3
Gene Name Name: BRD3
Synonyms:KIAA0043,RING3L;
Organism Homo sapiens (Human)

PRO ID PR:Q15059
DAG View
PRO Name bromodomain-containing protein 3 (human)
Definition A bromodomain-containing protein 3 that is encoded in the genome of human.
Short Label hBRD3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15059 (BRD3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
T15 Phosphorylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
T85 Phosphorylation PhosphoSitePlus
S165 O-Glycosylation GlyGen 35138101, 31492838, 29351928, ...34019948, 22564745, 32119511
S178 O-Glycosylation GlyGen 35138101, 31492838, 29351928, ...34019948, 22564745, 32119511
T181 O-Glycosylation GlyGen 35138101, 31492838, 29351928, ...34019948, 22564745, 32119511
T248 O-Glycosylation GlyGen 35138101, 31492838, 29351928, ...34019948, 22564745, 32119511
T249 O-Glycosylation GlyGen 35138101, 31492838, 29351928, ...34019948, 22564745, 32119511
T250 Phosphorylation PhosphoSitePlus
T253 O-Glycosylation GlyGen 35138101, 31492838, 29351928, ...34019948, 22564745, 32119511
S254 Phosphorylation PhosphoSitePlus
T257 Phosphorylation PhosphoSitePlus
S259 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S261 Phosphorylation PhosphoSitePlus
S263 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983, ...15302935, 18669648, 23186163, 20068231
S268 Phosphorylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
S281 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 24275569
K304 Acetylation PhosphoSitePlus
K304 Methylation PhosphoSitePlus
K305 Acetylation PhosphoSitePlus
K305 Methylation PhosphoSitePlus
K307 Acetylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
R411 Methylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus
S563 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 21406692
K591 Ubiquitination PhosphoSitePlus
S609 Phosphorylation PhosphoSitePlus
K655 Acetylation PhosphoSitePlus
K666 Acetylation PhosphoSitePlus
S676 Phosphorylation PhosphoSitePlus
S680 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S681 Phosphorylation PhosphoSitePlus
S682 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S703 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
S706 Phosphorylation PhosphoSitePlus
S707 Phosphorylation PhosphoSitePlus
S708 Phosphorylation PhosphoSitePlus
S710 Phosphorylation PhosphoSitePlus
S712 Phosphorylation PhosphoSitePlus
S716 Phosphorylation PhosphoSitePlus
S718 Phosphorylation PhosphoSitePlus
S719 Phosphorylation PhosphoSitePlus
S720 Phosphorylation PhosphoSitePlus
S722 Phosphorylation PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus
S725 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S254 Phosphorylation HPRD 20068231
S259 Phosphorylation HPRD 17287340
S261 Phosphorylation HPRD 20058876
S263 Phosphorylation HPRD 19413330, 17322306, 17287340, ...18212344, 18767875, 19664994, 19664995, 19651622, 18669648, 20058876, 20166139, 20068231, 20068230
S281 Phosphorylation HPRD 18767875, 17287340
S563 Phosphorylation HPRD 19413330, 15302935, 19664995, ...18452278, 19651622, 18669648, 20068231
S680 Phosphorylation HPRD 20068231
S682 Phosphorylation HPRD 17924679


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 F2 Biomuta DOID:4159 / skin cancer [ cosmic ]
T253 M253 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S268 L268 Biomuta [ cosmic ]
K304 E304 Biomuta DOID:1612 / breast cancer [ cosmic ]
S609 F609 Biomuta DOID:5041 / esophageal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
K655 R655 Biomuta DOID:4159 / skin cancer [ cosmic ]
S676 N676 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S680 R680 Biomuta DOID:3571 / liver cancer [ cosmic ]
S680 I680 Biomuta DOID:4159 / skin cancer [ cosmic ]