iPTMnet Report for Q15057 (ACAP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15057 / ACAP2_HUMAN
Protein Name Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
Gene Name Name: ACAP2
Synonyms:CENTB2,KIAA0041;
Organism Homo sapiens (Human)

PRO ID PR:Q15057
DAG View
PRO Name Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (human)
Definition An Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 that is encoded in the genome of human.
Short Label hACAP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15057 (ACAP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K57 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
Y197 Phosphorylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
Y259 Phosphorylation PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
Y298 Phosphorylation PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
S345 O-Glycosylation GlyGen 29351928
K347 Ubiquitination PhosphoSitePlus
T358 Phosphorylation PhosphoSitePlus
K367 Acetylation PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
S378 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S379 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648, 15302935
S381 Phosphorylation PhosphoSitePlus
T382 Phosphorylation PhosphoSitePlus
S384 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18669648, 15302935
S387 Phosphorylation PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
K515 Acetylation PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
S521 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 20058876, ...19664994, 17322306, 20068231
K527 Acetylation PhosphoSitePlus
K532 Acetylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
S563 Phosphorylation PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus   UniProt 23186163
S584 Phosphorylation PhosphoSitePlus
Y586 Phosphorylation HPRD   PhosphoSitePlus 18707149
S595 Phosphorylation PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus
K602 Ubiquitination PhosphoSitePlus
K617 Acetylation PhosphoSitePlus
K695 Acetylation PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
S738 Phosphorylation PhosphoSitePlus
Y742 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455
T749 Phosphorylation PhosphoSitePlus
Y750 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15592455
K767 Ubiquitination PhosphoSitePlus
S775 Phosphorylation HPRD   PhosphoSitePlus   UniProt 17525332, 23186163


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T358 N358 Biomuta DOID:3571 / liver cancer [ cosmic ]
K367 N367 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K377 I377 Biomuta DOID:263 / kidney cancer [ cosmic ]
S379 C379 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S517 C517 Biomuta DOID:1324 / lung cancer [ cosmic ]
S517 F517 Biomuta DOID:4159 / skin cancer [ cosmic ]
S519 L519 Biomuta DOID:4159 / skin cancer [ cosmic ]
S519 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
S595 Y595 Biomuta DOID:363 / uterine cancer [ icgc ]