iPTMnet Report for Q15022 (SUZ12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15022 / SUZ12_HUMAN
Protein Name Polycomb protein SUZ12
Gene Name Name: SUZ12
Synonyms:CHET9,JJAZ1,KIAA0160;
Organism Homo sapiens (Human)

PRO ID PR:Q15022
DAG View
PRO Name polycomb protein SUZ12 (human)
Definition A polycomb protein SUZ12 that is encoded in the genome of human.
Short Label hSUZ12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15022 (SUZ12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Methylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus   UniProt 23186163
S37 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K72 Sumoylation PhosphoSitePlus
K73 Sumoylation PhosphoSitePlus
K75 Sumoylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
T116 O-Glycosylation GlyGen 30379171, 35083852, 29351928
T131 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
K140 Acetylation PhosphoSitePlus
K140 Sumoylation PhosphoSitePlus
K143 Acetylation PhosphoSitePlus
K145 Acetylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K223 Sumoylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K246 Acetylation PhosphoSitePlus
Y248 Phosphorylation PhosphoSitePlus
T255 Phosphorylation PhosphoSitePlus
T336 Phosphorylation PhosphoSitePlus
K341 Acetylation PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
T379 Phosphorylation PhosphoSitePlus
S382 Phosphorylation PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
K403 Methylation PhosphoSitePlus
T412 Phosphorylation PhosphoSitePlus
K414 Methylation PhosphoSitePlus
T418 Phosphorylation HPRD 17693683
C494 Methylation IEDB 31844290
K537 Ubiquitination PhosphoSitePlus
S539 Phosphorylation P53350 (PLK1) HPRD   PhosphoSitePlus 25855382, 19691289
S541 Phosphorylation P53350 (PLK1) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 25855382, 18669648, 23186163
S546 Phosphorylation P53350 (PLK1) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17322306, 21406692, ...23186163, 17081983, 18220336, 18767875, 15302935, 19664995, 18452278, 19651622, 18669648, 25855382, 19690332, 20068231
S568 Phosphorylation HPRD 17081983
T570 Phosphorylation HPRD   PhosphoSitePlus 17081983
S583 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18452278, 17081983, ...18220336
K595 Ubiquitination PhosphoSitePlus
S604 Phosphorylation PhosphoSitePlus
K687 Ubiquitination PhosphoSitePlus
S693 Phosphorylation PhosphoSitePlus
S695 Phosphorylation HPRD   PhosphoSitePlus 20068231, 18452278
T724 Phosphorylation HPRD 20068231
S726 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 19007248


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S37 L37 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K72 R72 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K92 N92 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
K143 E143 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K223 * Biomuta DOID:263 / kidney cancer [ cosmic ]
K395 E395 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T418 A418 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C494 Y494 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
C494 F494 Biomuta DOID:3571 / liver cancer [ cosmic ]
S568 G568 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S583 I583 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S604 C604 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S693 F693 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S693 P693 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]