iPTMnet Report for Q14934 (NFATC4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14934 / NFAC4_HUMAN
Protein Name Nuclear factor of activated T-cells, cytoplasmic 4
Gene Name Name: NFATC4
Synonyms:NFAT3;
Organism Homo sapiens (Human)

PRO ID PR:Q14934
DAG View
PRO Name nuclear factor of activated T-cells, cytoplasmic 4 (human)
Definition A nuclear factor of activated T-cells, cytoplasmic 4 that is encoded in the genome of human.
Short Label hNFATC4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14934 (NFATC4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
S168 Phosphorylation Q16539 (MAPK14) , O15264 (MAPK13) , Q15759 (MAPK11) , P53778 (MAPK12) , Q13164 (MAPK7) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11997522, 27307045, 18347059, ...17194453
S170 Phosphorylation Q13164 (MAPK7) , P53778 (MAPK12) , Q16539 (MAPK14) , O15264 (MAPK13) , Q15759 (MAPK11) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11997522, 27307045, 18347059, ...17194453
S173 Phosphorylation PhosphoSitePlus
S213 Phosphorylation P45983 (MAPK8) , P45984 (MAPK9) neXtProt   PhosphoSitePlus   UniProt 17875713
S217 Phosphorylation P45984 (MAPK9) , P45983 (MAPK8) neXtProt   PhosphoSitePlus   UniProt 17875713
S221 Phosphorylation PhosphoSitePlus
T226 Phosphorylation PhosphoSitePlus
Y234 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
T256 Phosphorylation PhosphoSitePlus
S259 Phosphorylation PhosphoSitePlus   RLIMS-P 27893713
S264 Phosphorylation PhosphoSitePlus
S272 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S281 Phosphorylation P51812 (RPS6KA3) PhosphoSitePlus 17213202
S285 Phosphorylation P51812 (RPS6KA3) PhosphoSitePlus 17213202
S289 Phosphorylation P51812 (RPS6KA3) PhosphoSitePlus   UniProt 17213202
S295 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
Y317 Phosphorylation PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
S334 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S335 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S344 Phosphorylation P51812 (RPS6KA3) PhosphoSitePlus   UniProt 17213202
S382 Phosphorylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
Y653 Phosphorylation PhosphoSitePlus
S654 Phosphorylation PhosphoSitePlus
S676 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) , P51812 (RPS6KA3) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 18086672, 15657420
T772 Phosphorylation PhosphoSitePlus
K858 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S168 Phosphorylation Q16539 (MAPK14) HPRD 11997522
S170 Phosphorylation Q16539 (MAPK14) HPRD 11997522
S213 Phosphorylation HPRD 19651622
S217 Phosphorylation HPRD 19651622
S221 Phosphorylation HPRD 19651622
Y234 Phosphorylation HPRD 19651622
S289 Phosphorylation HPRD 19651622, 17081983
Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S73 L73 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S217 L217 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T226 S226 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S259 F259 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S272 P272 Biomuta DOID:263 / kidney cancer [ cosmic ]
S281 F281 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S676 N676 Biomuta DOID:9256 / colorectal cancer [ cosmic ]