iPTMnet Report Q14831 GRM7

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q14831 / GRM7_HUMAN
Protein Name	Metabotropic glutamate receptor 7 precursor
Gene Name	Name: GRM7 Synonyms:GPRC1G,MGLUR7;
Organism	Homo sapiens (Human)

PRO ID	PR:Q14831 DAG View
PRO Name	metabotropic glutamate receptor 7 (human)
Definition	A metabotropic glutamate receptor 7 that is encoded in the genome of human.
Short Label	hGRM7
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q14831 (GRM7) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T12	Phosphorylation		score1	PhosphoSitePlus
	T223	Phosphorylation		score1	PhosphoSitePlus
	S226	Phosphorylation		score1	PhosphoSitePlus
	S229	Phosphorylation		score1	PhosphoSitePlus
	T264	Phosphorylation		score1	PhosphoSitePlus
	T386	Phosphorylation		score1	PhosphoSitePlus
	T675	Phosphorylation		score1	PhosphoSitePlus
	T677	Phosphorylation		score1	PhosphoSitePlus
	T822	Phosphorylation		score1	PhosphoSitePlus
	S862	Phosphorylation		score4	IEDB PhosphoSitePlus RLIMS-P	12021391, 35494241
	S874	Phosphorylation		score1	PhosphoSitePlus
	K889	Sumoylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T264	Phosphorylation		score0	HPRD	19664994
	T675	Phosphorylation		score0	HPRD	18491316
	T677	Phosphorylation		score0	HPRD	18491316

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T264	Phosphorylation		score0	HPRD	19664994
	T675	Phosphorylation		score0	HPRD	18491316
	T677	Phosphorylation		score0	HPRD	18491316

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
T223	I223	Biomuta		DOID:4159 / skin cancer [ cosmic, icgc ]
S226	*	Biomuta		DOID:5041 / esophageal cancer [ tcga ]
S226	L226	Biomuta		DOID:4159 / skin cancer [ cosmic, icgc ]
S229	T229	Biomuta		DOID:1324 / lung cancer [ cosmic, icgc ]
T264	I264	Biomuta		DOID:363 / uterine cancer [ icgc ]
T386	K386	Biomuta		DOID:1324 / lung cancer [ cosmic, icgc ]
T675	K675	Biomuta		DOID:1324 / lung cancer [ cosmic ]
T675	M675	Biomuta		DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ]
T677	R677	Biomuta		DOID:1324 / lung cancer [ cosmic ]
S874	L874	Biomuta		DOID:1324 / lung cancer [ cosmic, cosmic, icgc, cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ]