iPTMnet Report for Q14739 (LBR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14739 / LBR_HUMAN
Protein Name Delta(14)-sterol reductase LBR
Gene Name Name: LBR
Organism Homo sapiens (Human)

PRO ID PR:Q14739
DAG View
PRO Name Delta(14)-sterol reductase LBR (human)
Definition A Delta(14)-sterol reductase LBR that is encoded in the genome of human.
Short Label hLBR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14739 (LBR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
R13 Methylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
Y22 Phosphorylation PhosphoSitePlus
Y23 Phosphorylation PhosphoSitePlus
T33 O-Glycosylation GlyGen 27655845, 33214551, 30379171, ...34725712, 29351928, 34019948, 35083852, 32119511, 28510447
S34 O-Glycosylation GlyGen 27655845, 33214551, 30379171, ...34725712, 29351928, 34019948, 35083852, 32119511, 28510447
K42 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K55 Acetylation PhosphoSitePlus   UniProt 19608861
K55 Ubiquitination PhosphoSitePlus
T58 Phosphorylation PhosphoSitePlus   UniProt 23186163
S59 Phosphorylation PhosphoSitePlus   UniProt 23186163
S67 Phosphorylation PhosphoSitePlus
S69 Phosphorylation PhosphoSitePlus
S71 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9045635, 14718546, 27802161, ...21795390, 20576617
S78 Phosphorylation HPRD 20068231
S80 Phosphorylation HPRD   RLIMS-P 27105349, 20068231
S82 Phosphorylation PhosphoSitePlus   RLIMS-P 27105349
S84 Phosphorylation HPRD   PhosphoSitePlus 19651622
S86 Phosphorylation P06493 (CDK1) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 19651622, 21795390, 14718546, ...27802161
S93 Phosphorylation PhosphoSitePlus
S97 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 20166139, 20068231
S99 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18707149, ...20166139, 20068231, 17924679
S101 Phosphorylation HPRD   PhosphoSitePlus 17081983
K107 Acetylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
T118 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 18669648, 21795390, ...20068231
K123 Acetylation PhosphoSitePlus
K123 Methylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus   UniProt 23186163
S130 Phosphorylation PhosphoSitePlus
Y132 Phosphorylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
Y161 Phosphorylation PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
Y166 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K183 Acetylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
Y187 Phosphorylation PhosphoSitePlus
K190 Acetylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
T200 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 21795390, 23186163
T284 Phosphorylation PhosphoSitePlus
C337 Methylation IEDB 31844290
S357 Phosphorylation PhosphoSitePlus
T380 Phosphorylation PhosphoSitePlus
Y385 Phosphorylation PhosphoSitePlus
C496 Methylation IEDB 31844290
S516 Phosphorylation PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
K594 Acetylation PhosphoSitePlus   UniProt 19608861
K594 Ubiquitination PhosphoSitePlus
K601 Acetylation PhosphoSitePlus   UniProt 19608861
K601 Methylation PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T33 N33 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S59 F59 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S80 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S86 F86 Biomuta DOID:4159 / skin cancer [ cosmic ]
S97 A97 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S99 F99 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S154 N154 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K186 T186 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T284 M284 Biomuta [ cosmic ] DOID:10534 / stomach cancer [ icgc ]
K519 E519 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K594 E594 Biomuta DOID:9256 / colorectal cancer [ cosmic ]