iPTMnet Report for Q14721 (KCNB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14721 / KCNB1_HUMAN
Protein Name Potassium voltage-gated channel subfamily B member 1
Gene Name Name: KCNB1
Organism Homo sapiens (Human)

PRO ID PR:Q14721
DAG View
PRO Name potassium voltage-gated channel subfamily B member 1 (human)
Definition A voltage-gated potassium channel KCNB1 that is encoded in the genome of human.
Short Label hKCNB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14721 (KCNB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
T93 Phosphorylation PhosphoSitePlus
Y99 Phosphorylation PhosphoSitePlus
Y128 Phosphorylation P12931 (SRC) HPRD   PhosphoSitePlus   Signor 19622611, 12615930
K149 Sumoylation PhosphoSitePlus
T359 Phosphorylation PhosphoSitePlus
T374 Phosphorylation PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
K474 Sumoylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
S500 Phosphorylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
S593 Phosphorylation UniProt 33124732
S607 Phosphorylation neXtProt 21712386
Y691 Phosphorylation PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus
T788 Phosphorylation PhosphoSitePlus
S800 Phosphorylation PhosphoSitePlus   RLIMS-P 23223293, 23857585, 33333928
T804 Phosphorylation PhosphoSitePlus
S805 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus 22745487, 17360683
S816 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y128 N128 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S457 G457 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S500 L500 Biomuta DOID:4159 / skin cancer [ cosmic ]
S723 Y723 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T788 K788 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T788 M788 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:2394 / ovarian cancer [ cosmic ]
S800 T800 Biomuta DOID:1324 / lung cancer [ cosmic ]
S816 F816 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]