iPTMnet Report for Q14680 (MELK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14680 / MELK_HUMAN
Protein Name Maternal embryonic leucine zipper kinase
Gene Name Name: MELK
Synonyms:KIAA0175;
Organism Homo sapiens (Human)

PRO ID PR:Q14680
DAG View
PRO Name maternal embryonic leucine zipper kinase (human)
Definition A maternal embryonic leucine zipper kinase that is encoded in the genome of human.
Short Label hMELK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14680 (MELK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K2 Ubiquitination PhosphoSitePlus
Y4 Phosphorylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
S49 O-Glycosylation GlyGen 30379171
S49 Phosphorylation PhosphoSitePlus
K55 Sumoylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
T56 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 16216881
T56 Phosphorylation Q14680 (MELK) neXtProt   PhosphoSitePlus   UniProt 16216881
K62 Ubiquitination PhosphoSitePlus
C70 Methylation IEDB 31844290
K134 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
Y163 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 16216881
Y163 Phosphorylation Q14680 (MELK) neXtProt   PhosphoSitePlus   UniProt 16216881
T167 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16628004, 23922895, 16216881, ...14976552
T167 Phosphorylation Q14680 (MELK) neXtProt   PhosphoSitePlus   Signor   UniProt 14976552, 16216881, 16628004
T167 Phosphorylation Q15831 (STK11) PhosphoSitePlus   Signor 16216881, 14976552
S171 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16216881
S171 Phosphorylation Q14680 (MELK) neXtProt   PhosphoSitePlus   Signor   UniProt 16216881
K225 Ubiquitination PhosphoSitePlus
Y226 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S253 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 16216881
S253 Phosphorylation Q14680 (MELK) neXtProt   PhosphoSitePlus   UniProt 16216881
K255 Ubiquitination PhosphoSitePlus
Y267 Phosphorylation PhosphoSitePlus
Y269 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
S336 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16216881
S336 Phosphorylation Q14680 (MELK) neXtProt   PhosphoSitePlus   UniProt 16216881
S338 Phosphorylation PhosphoSitePlus
S343 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 16628004, 16216881
S343 Phosphorylation Q14680 (MELK) neXtProt   PhosphoSitePlus   UniProt 16216881, 16628004
T345 Phosphorylation PhosphoSitePlus
T348 Phosphorylation PhosphoSitePlus
S356 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 18691976, 23186163, 19369195, ...16628004, 16216881, 19690332
S356 Phosphorylation Q14680 (MELK) neXtProt   PhosphoSitePlus   Signor   UniProt 16216881, 16628004
S363 Phosphorylation PhosphoSitePlus
Y367 Phosphorylation PhosphoSitePlus   UniProt 16628004
Y367 Phosphorylation Q14680 (MELK) PhosphoSitePlus 16628004
T387 Phosphorylation PhosphoSitePlus 16628004
T387 Phosphorylation Q14680 (MELK) PhosphoSitePlus 16628004
S391 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 16216881
S391 Phosphorylation Q14680 (MELK) neXtProt   PhosphoSitePlus   Signor   UniProt 16216881
K395 Ubiquitination PhosphoSitePlus
T398 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 16628004, 16216881
T398 Phosphorylation Q14680 (MELK) neXtProt   PhosphoSitePlus   Signor   UniProt 16216881, 16628004
S400 Phosphorylation PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus 16628004
S405 Phosphorylation Q14680 (MELK) PhosphoSitePlus 16628004
K406 Sumoylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
S407 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 16216881
S407 Phosphorylation Q14680 (MELK) neXtProt   PhosphoSitePlus   Signor   UniProt 16216881
T409 Phosphorylation PhosphoSitePlus   UniProt 16628004
T409 Phosphorylation Q14680 (MELK) PhosphoSitePlus 16628004
T415 Phosphorylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
Y427 Phosphorylation PhosphoSitePlus
T428 Phosphorylation PhosphoSitePlus
S431 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18669648, 16628004, 16216881
S431 Phosphorylation Q14680 (MELK) neXtProt   PhosphoSitePlus   Signor   UniProt 16216881, 16628004
K434 Sumoylation PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
Y438 Phosphorylation PhosphoSitePlus 16628004
Y438 Phosphorylation Q14680 (MELK) PhosphoSitePlus 16628004
T446 Phosphorylation PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
T460 Phosphorylation PhosphoSitePlus
R463 Methylation PhosphoSitePlus
T466 Phosphorylation PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
T478 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14699119
K481 Ubiquitination PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
T489 Phosphorylation PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
T494 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 16628004, 16216881
T494 Phosphorylation Q14680 (MELK) neXtProt   PhosphoSitePlus   Signor   UniProt 16216881, 16628004
S498 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
S505 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19369195, 23186163, 17081983, ...18691976, 18669648, 16216881, 16628004
S505 Phosphorylation Q14680 (MELK) neXtProt   PhosphoSitePlus   Signor   UniProt 16216881, 16628004
T518 Phosphorylation PhosphoSitePlus   UniProt 18691976
K520 Ubiquitination PhosphoSitePlus
K525 Sumoylation PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
S529 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 19369195, 23186163, 18691976, ...16216881, 16628004
S529 Phosphorylation Q14680 (MELK) neXtProt   PhosphoSitePlus   Signor   UniProt 16216881, 16628004
K536 Ubiquitination PhosphoSitePlus
T539 Phosphorylation IEDB   neXtProt   PhosphoSitePlus   Signor   UniProt 35494241, 16216881
T539 Phosphorylation Q14680 (MELK) neXtProt   PhosphoSitePlus   Signor   UniProt 16216881
T542 Phosphorylation PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
K639 Methylation PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus
K650 Methylation PhosphoSitePlus
K650 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S335 Phosphorylation HPRD 18691976
S336 Phosphorylation HPRD 18669648
S356 Phosphorylation HPRD 18691976, 19664994
S431 Phosphorylation HPRD 18669648
Y438 Phosphorylation HPRD 17016520, 19901323
T446 Phosphorylation HPRD 18691976
T460 Phosphorylation HPRD 18691976
T478 Phosphorylation HPRD 18691976
S486 Phosphorylation HPRD 18691976
T494 Phosphorylation HPRD 18691976
S498 Phosphorylation HPRD 18691976
S505 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983, 18452278
T518 Phosphorylation HPRD 18691976
S529 Phosphorylation HPRD 18691976


Q14680 (MELK) as PTM Enzyme



Substrate Site Score Source PMID
O15105 (SMAD7) T96 neXtProt 20659902
O15530 (PDPK1) T354 neXtProt 22544756
P04637 (TP53) S15 neXtProt 22532570
P23588 (EIF4B) S406 RLIMS-P+ 27528663
P30305 (CDC25B) S169 neXtProt   PhosphoSitePlus   Signor 15908796
P30305 (CDC25B) S219 Signor 12400006
P30305-3 (CDC25B) S280 HPRD 12400006
P30305-2 (CDC25B) S307 HPRD 12400006
P30305-1 (CDC25B) S321 HPRD 12400006
P30305 (CDC25B) S323 neXtProt   PhosphoSitePlus 12400006
P84022 (SMAD3) S204 neXtProt 20659902
Q13485 (SMAD4) S343 neXtProt 20659902
Q14680 (MELK) T56 neXtProt   PhosphoSitePlus   UniProt 16216881
Q14680 (MELK) Y163 neXtProt   PhosphoSitePlus   UniProt 16216881
Q14680 (MELK) T167 neXtProt   PhosphoSitePlus   Signor   UniProt 14976552, 16216881, 16628004
Q14680 (MELK) S171 neXtProt   PhosphoSitePlus   Signor   UniProt 16216881
Q14680 (MELK) S253 neXtProt   PhosphoSitePlus   UniProt 16216881
Q14680 (MELK) S336 neXtProt   PhosphoSitePlus   UniProt 16216881
Q14680 (MELK) S343 neXtProt   PhosphoSitePlus   UniProt 16216881, 16628004
Q14680 (MELK) S356 neXtProt   PhosphoSitePlus   Signor   UniProt 16216881, 16628004
Q14680 (MELK) Y367 PhosphoSitePlus 16628004
Q14680 (MELK) T387 PhosphoSitePlus 16628004
Q14680 (MELK) S391 neXtProt   PhosphoSitePlus   Signor   UniProt 16216881
Q14680 (MELK) T398 neXtProt   PhosphoSitePlus   Signor   UniProt 16216881, 16628004
Q14680 (MELK) S405 PhosphoSitePlus 16628004
Q14680 (MELK) S407 neXtProt   PhosphoSitePlus   Signor   UniProt 16216881
Q14680 (MELK) T409 PhosphoSitePlus 16628004
Q14680 (MELK) S431 neXtProt   PhosphoSitePlus   Signor   UniProt 16216881, 16628004
Q14680 (MELK) Y438 PhosphoSitePlus 16628004
Q14680 (MELK) T494 neXtProt   PhosphoSitePlus   Signor   UniProt 16216881, 16628004
Q14680 (MELK) S505 neXtProt   PhosphoSitePlus   Signor   UniProt 16216881, 16628004
Q14680 (MELK) S529 neXtProt   PhosphoSitePlus   Signor   UniProt 16216881, 16628004
Q14680 (MELK) T539 neXtProt   PhosphoSitePlus   Signor   UniProt 16216881
Q15796 (SMAD2) S245 neXtProt 20659902
Q99683 (MAP3K5) T838 neXtProt 18948261


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y4 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y163 H163 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S236 I236 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S253 C253 Biomuta DOID:1324 / lung cancer [ cosmic ]
S253 Y253 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T345 I345 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T348 I348 Biomuta DOID:1324 / lung cancer [ cosmic ]
S391 L391 Biomuta DOID:4159 / skin cancer [ cosmic ]
K395 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S400 P400 Biomuta DOID:184 / bone cancer [ cosmic ]
S407 * Biomuta DOID:4159 / skin cancer [ cosmic ]
T428 A428 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
K434 N434 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T460 M460 Biomuta DOID:2394 / ovarian cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
R463 C463 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S486 P486 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S505 L505 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K536 N536 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S544 N544 Biomuta DOID:4159 / skin cancer [ cosmic ]
K639 Q639 Biomuta DOID:3571 / liver cancer [ cosmic, tcga ]
K639 N639 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]