iPTMnet Report for Q14671 (PUM1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14671 / PUM1_HUMAN
Protein Name Pumilio homolog 1
Gene Name Name: PUM1
Synonyms:KIAA0099;
Organism Homo sapiens (Human)

PRO ID PR:Q14671
DAG View
PRO Name pumilio homolog 1 (human)
Definition A pumilio homolog 1 that is encoded in the genome of human.
Short Label hPUM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14671 (PUM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
K8 Methylation PhosphoSitePlus
S17 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S19 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
S75 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...19690332
Y83 Phosphorylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus   UniProt 20068231
S106 Phosphorylation PhosphoSitePlus   UniProt 20068231
K107 Ubiquitination PhosphoSitePlus
T112 Phosphorylation PhosphoSitePlus   UniProt 23186163
S124 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K150 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
S158 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 30059200, 28657654, 35254053, 35132862, 30620550, 29351928, 22121020, 31373491, 29237092
S159 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 30059200, 28657654, 35254053, 35132862, 30620550, 29351928, 22121020, 31373491, 29237092
S159 Phosphorylation PhosphoSitePlus   UniProt 23186163
K160 Ubiquitination PhosphoSitePlus
S180 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 30059200, 28657654, 35254053, 35132862, 30620550, 29351928, 22121020, 31373491, 29237092
S185 O-Glycosylation GlyGen 31373491
S185 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus   UniProt 23186163
S202 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
S209 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 20818387, ...18669648, 19690332, 20068231
S212 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 30059200, 28657654, 35254053, 35132862, 30620550, 29351928, 22121020, 31373491, 29237092
S214 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
Y224 Phosphorylation PhosphoSitePlus
S228 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S229 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S233 Phosphorylation PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
R243 Methylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
T260 Phosphorylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
T298 Phosphorylation PhosphoSitePlus
T514 Phosphorylation PhosphoSitePlus
R580 Methylation PhosphoSitePlus
S665 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 30059200, 28657654, 35254053, 35132862, 30620550, 29351928, 22121020, 31373491, 29237092
S709 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
T711 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S713 Phosphorylation PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus   UniProt 20818387
Y717 Phosphorylation PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
T720 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 30059200, 28657654, 35254053, 35132862, 30620550, 29351928, 22121020, 31373491, 29237092
S721 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 30059200, 28657654, 35254053, 35132862, 30620550, 29351928, 22121020, 31373491, 29237092
S722 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 30059200, 28657654, 35254053, 35132862, 30620550, 29351928, 22121020, 31373491, 29237092
Y784 Phosphorylation PhosphoSitePlus
S786 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 30059200, 28657654, 35254053, 35132862, 30620550, 31492838, 29351928, 22121020, 31373491, 29237092
K794 Acetylation PhosphoSitePlus
K794 Ubiquitination PhosphoSitePlus
Y795 Phosphorylation PhosphoSitePlus
R796 Methylation PhosphoSitePlus   UniProt 24129315
S797 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 30059200, 28657654, 35254053, 35132862, 30620550, 31492838, 29351928, 22121020, 31373491, 29237092
S797 Phosphorylation PhosphoSitePlus
S799 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 30059200, 28657654, 35254053, 35132862, 30620550, 29351928, 22121020, 31373491, 29237092
S799 Phosphorylation PhosphoSitePlus
S800 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 30059200, 28657654, 35254053, 35132862, 30620550, 31492838, 29351928, 22121020, 31373491, 29237092
S802 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 30059200, 28657654, 35254053, 35132862, 30620550, 29351928, 22121020, 31373491, 29237092
S803 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 30059200, 28657654, 35254053, 35132862, 30620550, 29351928, 22121020, 31373491, 29237092
S803 Phosphorylation PhosphoSitePlus
S806 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 30059200, 28657654, 35254053, 35132862, 30620550, 29351928, 22121020, 31373491, 29237092
S806 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S808 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 30059200, 28657654, 35254053, 35132862, 30620550, 29351928, 22121020, 31373491, 29237092
S808 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S809 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 30059200, 28657654, 35254053, 35132862, 30620550, 29351928, 22121020, 31373491, 29237092
S809 Phosphorylation PhosphoSitePlus
T810 O-Glycosylation GlyGen 31373491
S813 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 30059200, 28657654, 35254053, 35132862, 30620550, 29351928, 22121020, 31373491, 29237092
S813 Phosphorylation PhosphoSitePlus
S814 Phosphorylation PhosphoSitePlus
S815 Phosphorylation PhosphoSitePlus
R818 Methylation PhosphoSitePlus
S822 Phosphorylation PhosphoSitePlus   UniProt 23186163
K869 Ubiquitination PhosphoSitePlus
K914 Ubiquitination PhosphoSitePlus
K940 Ubiquitination PhosphoSitePlus
K963 Ubiquitination PhosphoSitePlus
K966 Ubiquitination PhosphoSitePlus
K976 Ubiquitination PhosphoSitePlus
C980 Methylation IEDB 31844290
K1058 Acetylation PhosphoSitePlus
S1073 Phosphorylation PhosphoSitePlus
K1084 Ubiquitination PhosphoSitePlus
C1085 Methylation IEDB 31844290
Y1113 Phosphorylation PhosphoSitePlus
Y1120 Phosphorylation PhosphoSitePlus
Y1123 Phosphorylation PhosphoSitePlus
K1127 Ubiquitination PhosphoSitePlus
T1150 Phosphorylation PhosphoSitePlus
K1158 Ubiquitination PhosphoSitePlus
K1163 Ubiquitination PhosphoSitePlus
K1166 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation HPRD 18669648
S19 Phosphorylation HPRD 18669648
T39 Phosphorylation HPRD 18691976
T60 Phosphorylation HPRD 20068231
S75 Phosphorylation HPRD 18669648
S98 Phosphorylation HPRD 20068231
Y103 Phosphorylation HPRD 20068231
S106 Phosphorylation HPRD 20068231
S124 Phosphorylation HPRD 19651622, 20068231
S197 Phosphorylation HPRD 17081983
S202 Phosphorylation HPRD 17081983
S209 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S228 Phosphorylation HPRD 18669648
S229 Phosphorylation HPRD 17322306, 18669648
S709 Phosphorylation HPRD 18691976, 18212344, 18767875, ...19664995, 19651622, 18669648, 18707149, 20068231
T711 Phosphorylation HPRD 19651622, 18669648
S714 Phosphorylation HPRD 17081983
S806 Phosphorylation HPRD 18669648, 19664995
S808 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
K914 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation HPRD 18669648
S19 Phosphorylation HPRD 18669648
T39 Phosphorylation HPRD 18691976
T60 Phosphorylation HPRD 20068231
S75 Phosphorylation HPRD 18669648
S98 Phosphorylation HPRD 20068231
Y103 Phosphorylation HPRD 20068231
S106 Phosphorylation HPRD 20068231
S124 Phosphorylation HPRD 19651622, 20068231
S197 Phosphorylation HPRD 17081983
S202 Phosphorylation HPRD 17081983
S209 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S228 Phosphorylation HPRD 18669648
S229 Phosphorylation HPRD 17322306, 18669648
S709 Phosphorylation HPRD 18691976, 18212344, 18767875, ...19664995, 19651622, 18669648, 18707149, 20068231
T711 Phosphorylation HPRD 19651622, 18669648
S714 Phosphorylation HPRD 17081983
S806 Phosphorylation HPRD 18669648, 19664995
S808 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S187 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S75 F75 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y83 H83 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ]
Y103 C103 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T112 S112 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S206 Y206 Biomuta DOID:363 / uterine cancer [ icgc ]
S220 I220 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T260 M260 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R580 * Biomuta DOID:4159 / skin cancer [ cosmic ]
T711 I711 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K718 N718 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T720 A720 Biomuta DOID:263 / kidney cancer [ cosmic ]
S721 L721 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S722 I722 Biomuta DOID:1324 / lung cancer [ cosmic ]
R796 C796 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S802 P802 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S803 G803 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S808 C808 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S808 I808 Biomuta DOID:1612 / breast cancer [ icgc ]
S813 A813 Biomuta DOID:3571 / liver cancer [ cosmic ]
R818 Q818 Biomuta DOID:363 / uterine cancer [ icgc ]
R818 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1058 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
T1150 A1150 Biomuta DOID:9256 / colorectal cancer [ icgc ]