iPTMnet Report Q14500 KCNJ12

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q14500 / KCJ12_HUMAN
Protein Name	ATP-sensitive inward rectifier potassium channel 12
Gene Name	Name: KCNJ12 Synonyms:IRK2,KCNJN1;
Organism	Homo sapiens (Human)

PRO ID	PR:Q14500 DAG View
PRO Name	ATP-sensitive inward rectifier potassium channel 12 (human)
Definition	An ATP-sensitive inward rectifier potassium channel 12 that is encoded in the genome of human.
Short Label	hKCNJ12
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q14500 (KCNJ12) as Substrate

Q14500

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T38	Phosphorylation		score1	PhosphoSitePlus
	S64	Phosphorylation		score1	PhosphoSitePlus
	T354	Phosphorylation		score1	PhosphoSitePlus
	S405	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	18669648
	S431	Phosphorylation	P17612 (PRKACA)	score3	HPRD neXtProt	11181181

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
T38	M38	Biomuta		DOID:1319 / brain cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T354	M354	Biomuta		DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
T354	K354	Biomuta		DOID:1324 / lung cancer [ cosmic, icgc ]
S405	I405	Biomuta		DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:1781 / thyroid cancer [ icgc ] DOID:2394 / ovarian cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]