iPTMnet Report for Q14449 (GRB14)
Protein Information
| UniProt AC / UniProt ID | Q14449 / GRB14_HUMAN |
| Protein Name | Growth factor receptor-bound protein 14 |
| Gene Name | Name: GRB14 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q14449 |
| PRO Name | growth factor receptor-bound protein 14 (human) |
| Definition | A growth factor receptor-bound protein 14 that is encoded in the genome of human. |
| Short Label | hGRB14 |
| Category | organism-gene |
DAG ViewQ14449 (GRB14) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T2 | Acetylation | score1 | UniProt | 19413330 | ||
| Q9 | Phosphorylation | score1 | UniProt | 24275569 | ||
| Y113 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y347 | Phosphorylation | score0 | RLIMS-P | 21791607 | ||
| S358 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 31347216 | ||
| S362 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 31347216 | ||
| S366 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P | 31347216, 24535599 | ||
| S370 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S372 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S375 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S419 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T421 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S423 | Phosphorylation | score1 | PhosphoSitePlus |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q14449 (GRB14) | Y347 | P18031 (PTPN1) | unknown | eFIP | 21791607 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S372 | P372 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S375 | F375 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S419 | I419 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| T421 | P421 | Biomuta | DOID:1612 / breast cancer [ cosmic ] |
