iPTMnet Report for Q14289 (PTK2B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14289 / FAK2_HUMAN
Protein Name Protein-tyrosine kinase 2-beta
Gene Name Name: PTK2B
Synonyms:FAK2,PYK2,RAFTK;
Organism Homo sapiens (Human)

PRO ID PR:Q14289
DAG View
PRO Name protein-tyrosine kinase 2-beta (human)
Definition A focal adhesion kinase 2 that is encoded in the genome of human.
Short Label hPTK2B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14289 (PTK2B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
S2 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus   RLIMS-P 9582355, 35607451
K12 Ubiquitination PhosphoSitePlus
T15 Phosphorylation PhosphoSitePlus
K35 Sumoylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
C120 Methylation IEDB 31844290
K145 Sumoylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
C246 Methylation IEDB 31844290
K295 Ubiquitination PhosphoSitePlus
C298 Methylation IEDB 31844290
K303 Ubiquitination PhosphoSitePlus
C310 Methylation IEDB 31844290
S332 Phosphorylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus   UniProt 19369195
S375 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18088087, 18691976, ...17192257, 23186163
S394 Phosphorylation PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus   RLIMS-P 18718528
S399 Phosphorylation PhosphoSitePlus   UniProt 19369195
Y402 Phosphorylation Q14289 (PTK2B) , P43405 (SYK) , P12931 (SRC) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 18535108, 17321230, 29133485, ...9242628, 15585656, 16574377, 11149930, 27613122, 11520052, 30571746, 18367725, 26866924, 20308428, 10867021, 9560226, 29920512, 23300847, 21859844, 29491534, 11820787, 26202465, 19861182, 20381867, 33277387, 24965120, 17581824, 17329398, 17055484, 30020827, 12231407, 11007796, 16414994, 11149924, 14996908, 26084289, 11493697, 8849729, 8816475, 20156366, 21429240, 30250159, 20028775, 15213840, 33785524, 15695828, 20826662, 20507587, 25090023, 25433371, 12514172, 15105428, 17188509, 19919693, 19380485, 20521079, 11602570, 30433799, 25889845, 15166227, 12063569, 20180987, 33273492, 19207108, 32792487, 22859931, 27602957, 29438996, 10521452
T409 Phosphorylation PhosphoSitePlus
Y418 Phosphorylation PhosphoSitePlus
Y440 Phosphorylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus   RLIMS-P 10788440, 16998541, 19144640, ...10637513, 25734515, 29432553, 16397254, 14637150, 24716819, 12164932, 12196460, 20153492, 35607451, 20668162, 10373549, 15181089, 10187855, 32238362, 16128807, 29595187, 27986865, 10385529, 11577096, 30301600, 31519735, 22314813, 26756739, 15347471, 32760285, 19933999, 11373274, 23690212, 11535620
K479 Ubiquitination PhosphoSitePlus
S530 Phosphorylation IEDB   PhosphoSitePlus 32387766
C534 Methylation IEDB 31844290
S559 Phosphorylation PhosphoSitePlus
K564 Acetylation PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus
Y573 Phosphorylation PhosphoSitePlus
Y579 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 12514172, 26484898, 17192257, ...33273492, 18083107, 10704819, 26866924, 29438996, 12522270, 10085136
Y580 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11820787, 15585656, 17188509, ...12514172, 16574377, 26484898, 15213840, 10704819, 23300847, 18083107, 20381867, 19412549, 10867021, 29438996, 12522270, 10085136, 20028775, 33273492
K581 Sumoylation PhosphoSitePlus
K581 Ubiquitination PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
Y683 Phosphorylation PhosphoSitePlus
Y699 Phosphorylation PhosphoSitePlus
T701 Phosphorylation PhosphoSitePlus
K703 Ubiquitination PhosphoSitePlus
S718 Phosphorylation PhosphoSitePlus
Y722 Phosphorylation PhosphoSitePlus   UniProt 19369195
S746 Phosphorylation PhosphoSitePlus
S747 Phosphorylation PhosphoSitePlus
T749 Phosphorylation PhosphoSitePlus
S752 Phosphorylation PhosphoSitePlus
Y756 Phosphorylation PhosphoSitePlus
S758 Phosphorylation PhosphoSitePlus
S762 Phosphorylation PhosphoSitePlus   UniProt 19369195
T765 Phosphorylation PhosphoSitePlus   UniProt 18691976
S778 Phosphorylation neXtProt   PhosphoSitePlus 22802128
K801 Ubiquitination PhosphoSitePlus
K810 Ubiquitination PhosphoSitePlus
Y819 Phosphorylation PhosphoSitePlus   UniProt 19369195
S828 Phosphorylation PhosphoSitePlus
Y834 Phosphorylation PhosphoSitePlus   UniProt 19369195
S839 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
T842 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
Y849 Phosphorylation PhosphoSitePlus   UniProt 19369195
T853 Phosphorylation PhosphoSitePlus
K858 Ubiquitination PhosphoSitePlus
S866 Phosphorylation PhosphoSitePlus   UniProt 19369195
Y881 Phosphorylation P12931 (SRC) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11820787, 15070849, 12514172, ...23922106, 8695788, 16774943, 33273492, 11007796, 10880513, 10867021, 20521079, 15126359, 29438996
K895 Sumoylation PhosphoSitePlus
Y906 Phosphorylation PhosphoSitePlus
K911 Ubiquitination PhosphoSitePlus
S923 Phosphorylation PhosphoSitePlus
K944 Ubiquitination PhosphoSitePlus
K948 Ubiquitination PhosphoSitePlus
K956 Ubiquitination PhosphoSitePlus
K973 Ubiquitination PhosphoSitePlus
K998 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S375 Phosphorylation Q14289 (PTK2B) HPRD 19651622, 18691976, 18088087, ...17192257, 20058876
S389 Phosphorylation HPRD 18691976
S394 Phosphorylation HPRD 18691976
S399 Phosphorylation HPRD 18691976
Y402 Phosphorylation Q14289 (PTK2B) HPRD   PRO 17684059, 9560226, 11698270, ...17205062
Y579 Phosphorylation Q14289 (PTK2B) HPRD   PRO 17016520, 11698270, 11337490
Y580 Phosphorylation Q14289 (PTK2B) HPRD   PRO 17016520, 11698270, 17389395, ...11337490
Y756 Phosphorylation HPRD 18691976
S758 Phosphorylation HPRD 18691976
S762 Phosphorylation HPRD 18691976
T765 Phosphorylation HPRD 18691976
S778 Phosphorylation Q14289 (PTK2B) HPRD 17192257
Y834 Phosphorylation HPRD 18691976
S839 Phosphorylation HPRD 18691976
T842 Phosphorylation HPRD 18691976
Y881 Phosphorylation Q14289 (PTK2B) HPRD   PRO 9560226, 11698270
Y906 Phosphorylation Q06124 (PTPN11) HPRD 10880513
Site PTM Type PTM Enzyme Score Source PMID
S375 Phosphorylation Q14289 (PTK2B) HPRD 19651622, 18691976, 18088087, ...17192257, 20058876
S389 Phosphorylation HPRD 18691976
S394 Phosphorylation HPRD 18691976
S399 Phosphorylation HPRD 18691976
Y402 Phosphorylation Q14289 (PTK2B) HPRD 17684059, 9560226, 17205062
Y579 Phosphorylation Q14289 (PTK2B) HPRD 17016520, 11337490
Y580 Phosphorylation Q14289 (PTK2B) HPRD 17016520, 11337490, 17389395
K734 Ubiquitination PhosphoSitePlus
Y792 Phosphorylation HPRD 18691976
S797 Phosphorylation HPRD 18691976
T800 Phosphorylation HPRD 18691976
Y839 Phosphorylation Q14289 (PTK2B) HPRD 9560226
Y864 Phosphorylation Q06124 (PTPN11) HPRD 10880513


Q14289 (PTK2B) as PTM Enzyme



Substrate Site Score Source PMID
O15259 (NPHP1) Y46 neXtProt   PhosphoSitePlus 21357692
O15259 (NPHP1) Y349 neXtProt   PhosphoSitePlus 21357692
O15259 (NPHP1) Y721 neXtProt 21357692
O43294 (TGFB1I1) Y60 PhosphoSitePlus 11856738
P29474 (NOS3) Y657 PhosphoSitePlus   Signor 18483407, 19934023
P37840-1 (SNCA) Y125 HPRD   PhosphoSitePlus 12096713, 11162638, 12893833, ...11744621
Q05397 (PTK2) Y407 HPRD   PhosphoSitePlus   Signor 16760434
Q14289-1 (PTK2B) S375 HPRD 19651622, 18691976, 18088087, ...17192257, 20058876
Q14289 (PTK2B) Y402 HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 12514172, 11493697, 17684059, ...17205062, 15105428, 9560226, 15166227
Q14289-2 (PTK2B) Y579 HPRD 17016520, 11337490
Q14289-1 (PTK2B) Y580 HPRD 17016520, 11337490, 17389395
Q14289-1 (PTK2B) S778 HPRD 17192257
Q14289-2 (PTK2B) Y839 HPRD 9560226
Q14289-1 (PTK2B) Y881 HPRD 9560226
Q658W2 (DKFZp666O0110) Y429 HPRD 16760434
Q9ULH1 (ASAP1) Y323 Signor 12771146
Q9ULH1 (ASAP1) Y767 neXtProt   Signor 12771146
Q9ULZ3 (PYCARD) Y146 RLIMS-P+ 27796369


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048953 (hPTK2B/Phos:2) pY402 PRO
PR:000048954 (hPTK2B/PhosTyr+) p PRO
PR:000036642 (hPTK2B/iso:1/Phos:1) pY402,pY579,pY580,pY881 PRO 11698270


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P78352 (DLG4) Y523 Q14289 (PTK2B) decreased_association eFIP 24981431
Phosphorylation Q14289 (PTK2B) Y402 P12931 (SRC) unknown eFIP 11149930
Phosphorylation Q14289 (PTK2B) Y402 Q96PH1 (NOX5) unknown eFIP 32792487
Phosphorylation Q14289 (PTK2B) Y402 P12931 (SRC) unknown eFIP 19380485
Phosphorylation Q14289 (PTK2B) Y402 P33151 (CDH5) unknown eFIP 20308428
Phosphorylation Q14289 (PTK2B) Y402 P05480 (Src) unknown eFIP 11149930
Phosphorylation Q96PH1 (NOX5) Y476 Q14289 (PTK2B) increased_association eFIP 32792487
Phosphorylation Q9UGK3 (STAP2) Y250 Q14289 (PTK2B) unknown eFIP 28478037