iPTMnet Report for Q14195 (DPYSL3)
Protein Information
| UniProt AC / UniProt ID | Q14195 / DPYL3_HUMAN |
| Protein Name | Dihydropyrimidinase-related protein 3 |
| Gene Name | Name: DPYSL3 Synonyms:CRMP4,DRP3,ULIP,ULIP1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q14195 |
| PRO Name | dihydropyrimidinase-related protein 3 (human) |
| Definition | A dihydropyrimidinase-related protein 3 that is encoded in the genome of human. |
| Short Label | hDPYSL3 |
| Category | organism-gene |
Q14195 (DPYSL3) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| Phosphorylation | score1 | PRO | ||||
| S2 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T13 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S14 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S30 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y32 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T102 | Phosphorylation | score1 | UniProt | 21406692, 17081983, 24275569 | ||
| C248 | Methylation | score1 | IEDB | 31844290 | ||
| Y251 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T253 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S257 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S259 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692 | ||
| S265 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S282 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S304 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S308 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K345 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K374 | Sumoylation | score1 | PhosphoSitePlus | |||
| K374 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S385 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K398 | Acetylation | score1 | PhosphoSitePlus | |||
| S402 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y431 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C448 | Methylation | score1 | IEDB | 31844290 | ||
| T462 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S472 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y499 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T507 | Phosphorylation | P24941 (CDK2) | score1 | PhosphoSitePlus | 18847512 | |
| T508 | Phosphorylation | P24941 (CDK2) | score1 | PhosphoSitePlus | 18847512 | |
| T509 | Phosphorylation | Q00535 (CDK5) , Q92630 (DYRK2) , P49841 (GSK3B) , P24941 (CDK2) | score4 | PRO PhosphoSitePlus RLIMS-P Signor UniProt | 21406692, 33893293, 15466863, ... | |
| K511 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T514 | Phosphorylation | P49841 (GSK3B) , Q92630 (DYRK2) , Q00535 (CDK5) | score4 | PRO PhosphoSitePlus RLIMS-P Signor UniProt | 21406692, 15466863, 33893293, ... | |
| S518 | Phosphorylation | Q00535 (CDK5) , Q92630 (DYRK2) , P49841 (GSK3B) | score4 | PRO PhosphoSitePlus RLIMS-P Signor UniProt | 15466863, 33893293, 16611631 | |
| R520 | Methylation | score1 | PhosphoSitePlus | |||
| S522 | Phosphorylation | Q92630 (DYRK2) , Q00535 (CDK5) | score4 | neXtProt PRO PhosphoSitePlus RLIMS-P UniProt | 21406692, 33893293, 15466863, ... | |
| T524 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S536 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S539 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S541 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T543 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S551 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R563 | Methylation | score1 | PhosphoSitePlus | |||
| S564 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T567 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S568 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S570 | Phosphorylation | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| T508 | Phosphorylation | score0 | HPRD | 20058876 | ||
| T509 | Phosphorylation | score0 | HPRD | 17322306, 18212344, 20058876, ... | ||
| T514 | Phosphorylation | score0 | HPRD | 19651622 | ||
| S518 | Phosphorylation | score0 | HPRD | 19651622 | ||
| S522 | Phosphorylation | score0 | HPRD | 19651622, 18578522, 17081983 | ||
| T524 | Phosphorylation | score0 | HPRD | 19651622 | ||
| S551 | Phosphorylation | score0 | HPRD | 17081983 |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S10 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y19 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K48 | Acetylation | score1 | PhosphoSitePlus | |||
| T49 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S56 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R60 | Methylation | score1 | PhosphoSitePlus | |||
| T64 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R73 | Methylation | score1 | PhosphoSitePlus | |||
| S75 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S77 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T85 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S95 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S102 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S112 | Phosphorylation | score1 | PhosphoSitePlus |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000047207 (hDPYSL3/Phos:1) | pS522 | PRO | |||
| PR:000047208 (hDPYSL3/Phos:2) | pT509,pT514,pS518,pS522 | PRO | |||
| PR:000047209 (hDPYSL3/PhosTyr+) | p | PRO |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| R60 | Q60 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| R73 | Q73 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| T85 | I85 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| T102 | A102 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S102 | P102 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| T462 | S462 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| T507 | I507 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| T509 | N509 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| R520 | Q520 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| R520 | W520 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
| S522 | C522 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
| S522 | F522 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S541 | P541 | Biomuta | DOID:2531 / hematologic cancer [ cosmic, icgc ] | |
| R563 | L563 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] |
DAG View