iPTMnet Report for Q14181 (POLA2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14181 / DPOA2_HUMAN
Protein Name DNA polymerase alpha subunit B
Gene Name Name: POLA2
Organism Homo sapiens (Human)

PRO ID PR:Q14181
DAG View
PRO Name DNA polymerase alpha subunit B (human)
Definition A DNA polymerase alpha subunit B that is encoded in the genome of human.
Short Label hPOLA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14181 (POLA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C31 Methylation IEDB 31844290
K72 Ubiquitination PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
T115 Phosphorylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
S126 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T127 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 15302935, ...18669648, 20068231
T130 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18669648, ...20068231, 17081983
T133 Phosphorylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
T139 Phosphorylation PhosphoSitePlus
S141 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
S147 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S149 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S150 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S152 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...18669648, 19690332, 20068231
S154 Phosphorylation PhosphoSitePlus   UniProt 23186163
T156 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
K160 Acetylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
C198 S-Nitrosylation dbSNO 19483679
K207 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
T317 Phosphorylation IEDB 32387766
K318 Sumoylation PhosphoSitePlus
C375 Methylation IEDB 31844290
K403 Ubiquitination PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
K549 Ubiquitination PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
C590 S-Nitrosylation dbSNO 26338901
Site PTM Type PTM Enzyme Score Source PMID
S126 Phosphorylation HPRD 19651622, 18669648, 20068231
T127 Phosphorylation HPRD 19413330, 16964243, 15302935, ...19664994, 19651622, 18669648, 20068231
T130 Phosphorylation HPRD 19413330, 19651622, 18669648, ...16964243, 20068231
S141 Phosphorylation HPRD 19651622, 12546699, 18669648, ...15302935, 20068231
S147 Phosphorylation HPRD 19651622, 18669648, 12546699, ...20068231
S149 Phosphorylation HPRD 18669648, 20068231
S150 Phosphorylation HPRD 18669648, 20068231
S152 Phosphorylation HPRD 19651622, 18669648, 15302935, ...20068231
S154 Phosphorylation HPRD 19651622
T156 Phosphorylation HPRD 20068231
S158 Phosphorylation HPRD 20068231
S229 Phosphorylation HPRD 20068231
Y575 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S147 L147 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S154 I154 Biomuta DOID:2021 / placenta cancer [ cosmic ]
K264 E264 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S418 F418 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S425 L425 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K564 T564 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C590 F590 Biomuta DOID:1319 / brain cancer [ icgc ]
C590 R590 Biomuta DOID:1319 / brain cancer [ cosmic ]