iPTMnet Report for Q14164 (IKBKE)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14164 / IKKE_HUMAN
Protein Name Inhibitor of nuclear factor kappa-B kinase subunit epsilon
Gene Name Name: IKBKE
Synonyms:IKKE,IKKI,KIAA0151;
Organism Homo sapiens (Human)

PRO ID PR:Q14164
DAG View
PRO Name inhibitor of nuclear factor kappa-B kinase subunit epsilon (human)
Definition An inhibitor of nuclear factor kappa-B kinase subunit epsilon that is encoded in the genome of human.
Short Label hIKBKE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14164 (IKBKE) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K25 Ubiquitination PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus   UniProt 23453969
K61 Ubiquitination PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
Y153 Phosphorylation PhosphoSitePlus   RLIMS-P 27287717
K154 Ubiquitination PhosphoSitePlus
S172 Phosphorylation O14920 (IKBKB) , Q14164 (IKBKE) , O15111 (CHUK) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19307177, 23478265, 21138416, ...11839743
Y179 Phosphorylation PhosphoSitePlus   RLIMS-P 27287717
K231 Sumoylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus   UniProt 23453969
K416 Ubiquitination PhosphoSitePlus
T463 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
T474 Phosphorylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
T501 Phosphorylation PhosphoSitePlus   UniProt 24882218
S519 Phosphorylation PhosphoSitePlus
S522 Phosphorylation PhosphoSitePlus
K549 Ubiquitination PhosphoSitePlus
K578 Ubiquitination PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
S664 Phosphorylation PhosphoSitePlus   UniProt 19369195
Y671 Phosphorylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
K677 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S172 Phosphorylation PRO 10421793
S664 Phosphorylation HPRD 18691976
Y671 Phosphorylation HPRD 18691976


Q14164 (IKBKE) as PTM Enzyme



Substrate Site Score Source PMID
O00571 (DDX3X) S102 PhosphoSitePlus 23478265
O14519 (CDK2AP1) S46 PhosphoSitePlus 22427660
O43524 (FOXO3) S644 PhosphoSitePlus   Signor 23691078
O43734 (TRAF3IP2) S328 neXtProt   Signor 21822257
O95786 (RIGI) S855 PhosphoSitePlus 26354181
P03372 (ESR1) S167 neXtProt   PhosphoSitePlus   Signor 19940156
P10914 (IRF1) S215 PhosphoSitePlus 24396068
P10914 (IRF1) S219 PhosphoSitePlus 24396068
P10914 (IRF1) S221 PhosphoSitePlus 24396068
P25963 (NFKBIA) S32 neXtProt   PhosphoSitePlus 10421793, 15879144, 10882136
P25963 (NFKBIA) S36 HPRD   neXtProt   PhosphoSitePlus 10421793, 15879144, 10882136
P31749 (AKT1) T308 neXtProt   PhosphoSitePlus 21908616, 21464307
P31749 (AKT1) S473 neXtProt   PhosphoSitePlus 21908616, 21464307
P42224 (STAT1) S727 Signor 17502367
P49840 (GSK3A) S21 PhosphoSitePlus 23142783
P98170 (XIAP) S430 PhosphoSitePlus 22072751
Q04206 (RELA) S468 neXtProt   PhosphoSitePlus   Signor 15489227, 16407239, 20507904
Q04206 (RELA) S536 neXtProt   PhosphoSitePlus   Signor 15489227, 16840782, 16407239, ...20507904
Q12933 (TRAF2) S11 neXtProt 23007157
Q14164 (IKBKE) S172 UniProt 23478265
Q14653 (IRF3) S386 PhosphoSitePlus 20604809, 20170763
Q14653 (IRF3) S396 neXtProt   PhosphoSitePlus 14739303, 16914100, 16199137, ...18272581, 20170763, 21138416
Q14653 (IRF3) S398 PhosphoSitePlus 20604809, 16914100
Q14653 (IRF3) S402 PhosphoSitePlus 18272581, 20170763, 16914100, ...20604809
Q5S007 (LRRK2) S910 neXtProt 22723946
Q5S007 (LRRK2) S935 neXtProt 22723946
Q92844 (TANK) S49 neXtProt 21138416, 10759890
Q92844 (TANK) S100 neXtProt 21138416, 10759890
Q92844 (TANK) S126 neXtProt 21138416, 10759890
Q92844 (TANK) S178 neXtProt 21138416, 10759890
Q92844 (TANK) S208 neXtProt 21138416, 10759890
Q92844 (TANK) S228 neXtProt 21138416, 10759890
Q92844 (TANK) S257 neXtProt 21138416, 10759890
Q92844 (TANK) S406 neXtProt 21138416, 10759890
Q92844 (TANK) S409 neXtProt 21138416, 10759890
Q92985 (IRF7) S471 PhosphoSitePlus   Signor 16914100, 10893229
Q92985 (IRF7) S472 PhosphoSitePlus   Signor 16914100, 10893229
Q92985 (IRF7) S477 PhosphoSitePlus 16914100
Q92985 (IRF7) S479 PhosphoSitePlus 16914100
Q96FA3 (PELI1) S76 PhosphoSitePlus 21204785
Q96FA3 (PELI1) T80 PhosphoSitePlus 21204785
Q96FA3 (PELI1) T288 PhosphoSitePlus 21204785
Q96FA3 (PELI1) S293 PhosphoSitePlus 21204785
Q9NQC7 (CYLD) S418 neXtProt 19481526
Q9Y6K9 (IKBKG) T50 neXtProt 21138416
Q9Y6K9 (IKBKG) S141 neXtProt 21138416
Q9Y6K9 (IKBKG) S148 neXtProt 21138416
Q9Y6K9 (IKBKG) S196 neXtProt 21138416
Q9Y6K9 (IKBKG) S208 neXtProt 21138416
Q9Y6K9 (IKBKG) S247 neXtProt 21138416


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028691 (hIKBKE/Phos:1) pS172 PRO 10421793


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K137 E137 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y153 C153 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K154 R154 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y179 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y179 C179 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y179 F179 Biomuta DOID:4159 / skin cancer [ cosmic ]
S464 F464 Biomuta DOID:4159 / skin cancer [ cosmic ]
S664 L664 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y671 S671 Biomuta DOID:1324 / lung cancer [ cosmic ]
K677 N677 Biomuta DOID:1319 / brain cancer [ cosmic ]