iPTMnet Report for Q14141 (SEPTIN6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14141 / SEPT6_HUMAN
Protein Name Septin-6
Gene Name Name: SEPTIN6
Synonyms:KIAA0128,SEP2,SEPT6;
Organism Homo sapiens (Human)

PRO ID PR:Q14141
DAG View
PRO Name septin-6 (human)
Definition A septin-6 that is encoded in the genome of human.
Short Label hSEPTIN6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14141 (SEPTIN6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 12665801
S27 Phosphorylation PhosphoSitePlus   UniProt 23186163
T65 Phosphorylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
C151 Methylation IEDB 31844290
K171 Ubiquitination PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
K196 Acetylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
Y295 Phosphorylation PhosphoSitePlus
Y298 Phosphorylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
T311 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
K316 Sumoylation PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
Y324 Phosphorylation PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K362 Acetylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
K367 Acetylation PhosphoSitePlus   UniProt 19608861
K367 Ubiquitination PhosphoSitePlus
K373 Acetylation PhosphoSitePlus
K379 Acetylation PhosphoSitePlus
K380 Acetylation PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus
K397 Acetylation PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
S408 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S411 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S416 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
T418 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17525332, 17287340
K420 Ubiquitination PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
C432 S-Nitrosylation dbSNO 26338901
Site PTM Type PTM Enzyme Score Source PMID
S408 Phosphorylation HPRD 17525332
S411 Phosphorylation HPRD 17525332
S416 Phosphorylation HPRD 19413330, 17525332
T418 Phosphorylation HPRD 17525332, 17287340
Site PTM Type PTM Enzyme Score Source PMID
S408 Phosphorylation HPRD 17525332
S411 Phosphorylation HPRD 17525332
S416 Phosphorylation HPRD 19413330, 17525332
T418 Phosphorylation HPRD 17525332, 17287340
Site PTM Type PTM Enzyme Score Source PMID
S408 Phosphorylation HPRD 17525332
S411 Phosphorylation HPRD 17525332
S416 Phosphorylation HPRD 19413330, 17525332
T418 Phosphorylation HPRD 17525332, 17287340


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C151 F151 Biomuta DOID:3571 / liver cancer [ cosmic ]
K171 R171 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K171 M171 Biomuta DOID:1324 / lung cancer [ cosmic ]
K176 E176 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K249 T249 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y295 S295 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y298 D298 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K309 N309 Biomuta DOID:363 / uterine cancer [ icgc ]
Y324 C324 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K327 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K362 N362 Biomuta DOID:363 / uterine cancer [ icgc ]
K367 T367 Biomuta DOID:1324 / lung cancer [ cosmic ]
K397 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S411 Y411 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T418 I418 Biomuta DOID:9256 / colorectal cancer [ cosmic, cosmic, cosmic ] DOID:2531 / hematologic cancer [ cosmic, cosmic ]