iPTMnet Report for Q14126 (DSG2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14126 / DSG2_HUMAN
Protein Name Desmoglein-2 precursor
Gene Name Name: DSG2
Synonyms:CDHF5;
Organism Homo sapiens (Human)

PRO ID PR:Q14126
DAG View
PRO Name desmoglein-2 (human)
Definition A desmoglein-2 that is encoded in the genome of human.
Short Label hDSG2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14126 (DSG2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
T53 O-Glycosylation GlyGen 25813380
S75 Phosphorylation PhosphoSitePlus
R81 Methylation PhosphoSitePlus
N112 N-Glycosylation GlyGen   UniProt 19159218, 24190977, 23090970, ...29391424, 29741879, 12754519
K141 Ubiquitination PhosphoSitePlus
N182 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 24190977, ...23090970, 19349973, 29741879
Y207 Phosphorylation PhosphoSitePlus
Y212 Phosphorylation PhosphoSitePlus
Y221 Phosphorylation PhosphoSitePlus
Y235 Phosphorylation PhosphoSitePlus
T291 Phosphorylation PhosphoSitePlus
N309 N-Glycosylation GlyGen 29741879
S363 Phosphorylation PhosphoSitePlus
R434 Methylation PhosphoSitePlus
N462 N-Glycosylation GlyGen   UniProt 24190977, 23090970, 29391424, ...19349973, 19139490, 29741879
T484 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
T552 Phosphorylation HPRD   PhosphoSitePlus 20068231
S559 Phosphorylation HPRD 20068231
K561 Ubiquitination PhosphoSitePlus
T645 Phosphorylation HPRD   PhosphoSitePlus 20068231
T650 Phosphorylation PhosphoSitePlus
K667 Ubiquitination PhosphoSitePlus
S680 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 18767875, 19664995, 18452278, 17322306, 18669648, 24275569, 19690332, 20068231
T695 Phosphorylation PhosphoSitePlus
K697 Methylation PhosphoSitePlus
K697 Ubiquitination PhosphoSitePlus
S699 Phosphorylation PhosphoSitePlus
S700 Phosphorylation PhosphoSitePlus   UniProt 24275569
S701 Phosphorylation PhosphoSitePlus
S703 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
K706 Ubiquitination PhosphoSitePlus
S712 Phosphorylation PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus   UniProt 23186163
S726 Phosphorylation PhosphoSitePlus   UniProt 23186163
T733 Phosphorylation HPRD 19691289
T744 Phosphorylation PhosphoSitePlus
T745 Phosphorylation PhosphoSitePlus
K746 Ubiquitination PhosphoSitePlus
R773 Methylation PhosphoSitePlus
Y775 Phosphorylation PhosphoSitePlus
K779 Ubiquitination PhosphoSitePlus
S782 Phosphorylation HPRD   PhosphoSitePlus 19691289, 20068231
Y783 Phosphorylation PhosphoSitePlus
N789 N-Glycosylation GlyGen 29391424
T791 Phosphorylation PhosphoSitePlus
C795 Methylation IEDB 31844290
T804 Phosphorylation PhosphoSitePlus   UniProt 24275569
S806 Phosphorylation PhosphoSitePlus   UniProt 24275569
S810 Phosphorylation PhosphoSitePlus   UniProt 24275569
S815 Phosphorylation PhosphoSitePlus   UniProt 24275569
K832 Ubiquitination PhosphoSitePlus
T835 Phosphorylation PhosphoSitePlus
K849 Ubiquitination PhosphoSitePlus
C871 Methylation IEDB 31844290
T874 Phosphorylation PhosphoSitePlus
T881 Phosphorylation PhosphoSitePlus
Y882 Phosphorylation PhosphoSitePlus
S884 Phosphorylation PhosphoSitePlus
S893 Phosphorylation PhosphoSitePlus
K901 Ubiquitination PhosphoSitePlus
T903 Phosphorylation HPRD   PhosphoSitePlus 19664994
S911 Phosphorylation PhosphoSitePlus
T922 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19691289, 24275569
S939 Phosphorylation PhosphoSitePlus
T942 Phosphorylation PhosphoSitePlus
Y968 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16212419
T973 Phosphorylation PhosphoSitePlus
Y979 Phosphorylation PhosphoSitePlus
T984 Phosphorylation PhosphoSitePlus
S999 Phosphorylation PhosphoSitePlus
Y1013 Phosphorylation HPRD   PhosphoSitePlus 19901323, 17081983
S1021 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1055 Phosphorylation PhosphoSitePlus
T1056 O-Glycosylation GlyGen 33214551, 31492838, 30620550, ...34019948, 32119511, 29237092, 30059200
T1056 Phosphorylation PhosphoSitePlus
S1059 Phosphorylation PhosphoSitePlus
S1060 Phosphorylation PhosphoSitePlus
Y1061 Phosphorylation PhosphoSitePlus
S1093 Phosphorylation PhosphoSitePlus
S1098 Phosphorylation PhosphoSitePlus
T1099 Phosphorylation PhosphoSitePlus
T1108 O-Glycosylation GlyGen 33214551, 31492838, 30620550, ...34019948, 32119511, 29237092, 30059200
K1109 Ubiquitination PhosphoSitePlus
S1111 Phosphorylation PhosphoSitePlus
Y1117 Phosphorylation PhosphoSitePlus
S1118 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T53 S53 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y212 C212 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T291 M291 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S363 L363 Biomuta DOID:4159 / skin cancer [ cosmic ]
S559 N559 Biomuta DOID:363 / uterine cancer [ icgc ]
K667 R667 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S700 R700 Biomuta DOID:363 / uterine cancer [ icgc ]
S703 F703 Biomuta DOID:4159 / skin cancer [ cosmic ]
S723 N723 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic ]
R773 K773 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y775 F775 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S806 L806 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
S810 F810 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S815 N815 Biomuta DOID:4159 / skin cancer [ cosmic ]
K849 N849 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S893 F893 Biomuta DOID:4159 / skin cancer [ cosmic ]
S893 Y893 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S911 Y911 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S939 Y939 Biomuta DOID:1324 / lung cancer [ cosmic ]
S999 L999 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S1055 F1055 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1093 F1093 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1111 T1111 Biomuta DOID:4159 / skin cancer [ cosmic ]