iPTMnet Report for Q14019 (COTL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14019 / COTL1_HUMAN
Protein Name Coactosin-like protein
Gene Name Name: COTL1
Synonyms:CLP;
Organism Homo sapiens (Human)

PRO ID PR:Q14019
DAG View
PRO Name coactosin-like protein (human)
Definition A coactosin-like protein that is encoded in the genome of human.
Short Label hCOTL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14019 (COTL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K4 Acetylation PhosphoSitePlus
K4 Ubiquitination PhosphoSitePlus
K7 Acetylation PhosphoSitePlus
K7 Ubiquitination PhosphoSitePlus
Y14 Phosphorylation PhosphoSitePlus
R57 Methylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
K72 Acetylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
K75 Acetylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
K102 Acetylation PhosphoSitePlus   UniProt 19608861
K102 Ubiquitination PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
S115 Phosphorylation phospho.ELM   PhosphoSitePlus 16097034
R117 Methylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K126 Acetylation PhosphoSitePlus   UniProt 19608861
K126 Sumoylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
S127 Phosphorylation HPRD   PhosphoSitePlus 18452278
K130 Acetylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
T141 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R57 Q57 Biomuta DOID:4159 / skin cancer [ cosmic ]
S71 R71 Biomuta DOID:3571 / liver cancer [ cosmic ]
K72 N72 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S115 R115 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S127 I127 Biomuta DOID:3571 / liver cancer [ cosmic ]
K131 N131 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T141 K141 Biomuta [ cosmic ]
T141 M141 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]