iPTMnet Report for Q13698 (CACNA1S)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13698 / CAC1S_HUMAN
Protein Name Voltage-dependent L-type calcium channel subunit alpha-1S
Gene Name Name: CACNA1S
Synonyms:CACH1,CACN1,CACNL1A3;
Organism Homo sapiens (Human)

PRO ID PR:Q13698
DAG View
PRO Name voltage-dependent L-type calcium channel subunit alpha-1S (human)
Definition A voltage-dependent L-type calcium channel subunit alpha-1S that is encoded in the genome of human.
Short Label hCACNA1S
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13698 (CACNA1S) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T225 Phosphorylation PhosphoSitePlus
T231 Phosphorylation PhosphoSitePlus
T236 Phosphorylation PhosphoSitePlus
T316 Phosphorylation IEDB 35494241
K343 Acetylation PhosphoSitePlus
K345 Acetylation PhosphoSitePlus
S346 O-Glycosylation GlyGen 30379171, 35254053
T349 O-Glycosylation GlyGen 30379171, 35254053
K352 Acetylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
Y399 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus
T476 Phosphorylation PhosphoSitePlus
T477 Phosphorylation PhosphoSitePlus
S687 Phosphorylation P17612 (PRKACA) HPRD   neXtProt   RLIMS-P 7629172, 2844809
T799 Phosphorylation PhosphoSitePlus
T802 Phosphorylation PhosphoSitePlus
Y971 Phosphorylation PhosphoSitePlus
Y972 Phosphorylation PhosphoSitePlus
Y973 Phosphorylation PhosphoSitePlus
Y975 Phosphorylation PhosphoSitePlus
Y1035 Phosphorylation PhosphoSitePlus
S1263 Phosphorylation PhosphoSitePlus
Y1269 Phosphorylation PhosphoSitePlus
Y1524 Phosphorylation PhosphoSitePlus
T1573 Phosphorylation PhosphoSitePlus
S1575 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 20937870
S1617 Phosphorylation P17612 (PRKACA) HPRD   neXtProt 2844809
K1716 Acetylation PhosphoSitePlus
K1723 Acetylation PhosphoSitePlus
S1757 Phosphorylation HPRD 1322891
S1854 Phosphorylation HPRD 1322891


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T225 I225 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S387 Y387 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ icgc ]
S393 Y393 Biomuta DOID:2394 / ovarian cancer [ icgc ]
S397 C397 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S473 C473 Biomuta DOID:3571 / liver cancer [ cosmic ]
S473 F473 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T477 N477 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T802 N802 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y1269 * Biomuta DOID:3571 / liver cancer [ cosmic ]
T1573 M1573 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1575 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S1617 F1617 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1757 F1757 Biomuta DOID:1324 / lung cancer [ cosmic ]