iPTMnet Report for Q13635 (PTCH1)
Protein Information
UniProt AC / UniProt ID | Q13635 / PTC1_HUMAN |
Protein Name | Protein patched homolog 1 |
Gene Name | Name: PTCH1 Synonyms:PTCH; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q13635 |
PRO Name | protein patched homolog 1 (human) |
Definition | A protein patched homolog 1 that is encoded in the genome of human. |
Short Label | hPTCH1 |
Category | organism-gene |
Q13635 (PTCH1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Ubiquitination | score1 | PRO | ||||
K163 | Ubiquitination | score1 | PhosphoSitePlus | |||
T368 | Phosphorylation | score1 | PhosphoSitePlus | |||
N414 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
S435 | Phosphorylation | score1 | PhosphoSitePlus | |||
S463 | Phosphorylation | score1 | PhosphoSitePlus | |||
K993 | Ubiquitination | score1 | PhosphoSitePlus | |||
T1195 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1197 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1331 | Phosphorylation | score1 | PhosphoSitePlus | |||
R1394 | Methylation | score1 | PhosphoSitePlus | |||
S1425 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S435 | F435 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
T1195 | S1195 | Biomuta | DOID:3565 / meningioma [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:11615 / penile cancer [ cosmic ] | |
T1195 | I1195 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
S1197 | F1197 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
R1394 | Q1394 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
R1394 | * | Biomuta | DOID:1319 / brain cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] | |
S1425 | L1425 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] |