iPTMnet Report for Q13586 (STIM1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13586 / STIM1_HUMAN
Protein Name Stromal interaction molecule 1 precursor
Gene Name Name: STIM1
Synonyms:GOK;
Organism Homo sapiens (Human)

PRO ID PR:Q13586
DAG View
PRO Name stromal interaction molecule 1 (human)
Definition A stromal interaction molecule 1 that is encoded in the genome of human.
Short Label hSTIM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13586 (STIM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation PhosphoSitePlus
C49 S-Nitrosylation dbSNO 26338901
N97 N-Glycosylation GlyGen 24190977
N131 N-Glycosylation GlyGen   UniProt 27865927, 11983428
K156 Ubiquitination PhosphoSitePlus
T170 O-Glycosylation GlyGen 33023909, 34019948, 28510447, ...30059200, 35254053
N171 N-Glycosylation GlyGen   UniProt 11983428, 19159218, 24190977, ...23090970, 16263699, 27865927, 29741879, 12754519
Y236 Phosphorylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus   UniProt 19367720, 23186163
K267 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
Y316 Phosphorylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
Y361 Phosphorylation PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
T389 Phosphorylation PhosphoSitePlus   RLIMS-P 29326165, 25504574
T393 Phosphorylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
T420 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus   RLIMS-P 19881501
S492 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T517 Phosphorylation PhosphoSitePlus   UniProt 24275569
S519 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
S521 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S523 Phosphorylation PhosphoSitePlus   UniProt 24275569
S524 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
S567 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S575 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 24114840, 23687376, 22298426, ...18669648, 25562429, 24095720, 25447552, 23186163, 28341841, 18088087, 19690332
K581 Ubiquitination PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
S602 Phosphorylation PhosphoSitePlus   UniProt 24275569
S608 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 23186163, 17081983, 23687376, ...18669648, 25562429, 24095720, 25447552, 24275569, 28341841
S616 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S618 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S620 Phosphorylation PhosphoSitePlus
S621 O-Glycosylation GlyGen   PhosphoSitePlus 33023909
S621 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 23186163, 23687376, 25562429, ...24095720, 25447552, 28341841
T626 O-Glycosylation GlyGen 33023909
T626 Phosphorylation PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus   UniProt 23186163
S660 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
T665 Phosphorylation PhosphoSitePlus   UniProt 19690332
S667 Phosphorylation PhosphoSitePlus
S668 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19881501, 18669648, 23186163, ...19690332
K677 Ubiquitination PhosphoSitePlus
K680 Acetylation PhosphoSitePlus
K681 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N171 N-Glycosylation PRO 29741879
S257 Phosphorylation HPRD 19651622, 20166139, 18578522
S512 Phosphorylation HPRD 18578522
T517 Phosphorylation HPRD 19651622, 20068231
S519 Phosphorylation HPRD 19651622, 20166139, 18669648, ...20068231
S521 Phosphorylation HPRD 19651622, 18767875, 20166139, ...17081983
S523 Phosphorylation HPRD 19651622
S524 Phosphorylation HPRD 20166139
S575 Phosphorylation HPRD 19413330, 18578522, 18088087, ...17081983, 19664994, 18669648, 19415658, 20068231, 17924679
S608 Phosphorylation HPRD 18669648, 17081983
S614 Phosphorylation HPRD 17081983
S616 Phosphorylation HPRD 19651622, 20166139, 18669648, ...20058876, 20068231
S618 Phosphorylation HPRD 20166139, 18669648, 20058876
S620 Phosphorylation HPRD 20058876
S621 Phosphorylation HPRD 20058876
T626 Phosphorylation HPRD 20068231
S628 Phosphorylation HPRD 20068231
S660 Phosphorylation HPRD 18669648, 18452278
T665 Phosphorylation HPRD 17081983
S667 Phosphorylation HPRD 20068231
S668 Phosphorylation HPRD 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13586 (STIM1) S575 Q4KMG0 (CDON) unknown eFIP 22298426
Phosphorylation Q13586 (STIM1) S621 Q15691 (MAPRE1) inhibited_association eFIP 24095720
Phosphorylation Q9HBA0 (TRPV4) S824 Q13586 (STIM1) unknown eFIP 25972993