iPTMnet Report for Q13576 (IQGAP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13576 / IQGA2_HUMAN
Protein Name Ras GTPase-activating-like protein IQGAP2
Gene Name Name: IQGAP2
Organism Homo sapiens (Human)

PRO ID PR:Q13576
DAG View
PRO Name Ras GTPase-activating-like protein IQGAP2 (human)
Definition A Ras GTPase-activating-like protein IQGAP2 that is encoded in the genome of human.
Short Label hIQGAP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13576 (IQGAP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y14 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 19690332, ...24275569
S24 Phosphorylation PhosphoSitePlus
Y38 Phosphorylation PhosphoSitePlus
Y74 Phosphorylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
Y189 Phosphorylation PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
Y285 Phosphorylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
T356 Phosphorylation PhosphoSitePlus   UniProt 24275569
S373 O-Glycosylation GlyGen 30379171, 29351928, 35254053
S396 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
Y494 Phosphorylation PhosphoSitePlus
Y499 Phosphorylation PhosphoSitePlus
K562 Ubiquitination PhosphoSitePlus
Y579 Phosphorylation PhosphoSitePlus
Y580 Phosphorylation PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus
S595 O-Glycosylation GlyGen 30379171, 29351928, 35254053
S595 Phosphorylation PhosphoSitePlus   UniProt 23186163
S596 O-Glycosylation GlyGen 30379171, 29351928, 35254053
S596 Phosphorylation PhosphoSitePlus
S599 O-Glycosylation GlyGen 30379171, 29351928, 35254053
S599 Phosphorylation PhosphoSitePlus   UniProt 24275569
K602 Ubiquitination PhosphoSitePlus
K608 Ubiquitination PhosphoSitePlus
Y609 Phosphorylation PhosphoSitePlus
Y611 Phosphorylation PhosphoSitePlus
Y612 Phosphorylation PhosphoSitePlus
Y613 Phosphorylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
T624 Phosphorylation PhosphoSitePlus
Y630 Phosphorylation PhosphoSitePlus
K631 Ubiquitination PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
S685 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y710 Phosphorylation PhosphoSitePlus
T716 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   RLIMS-P   UniProt 21460214, 24275569
T735 Phosphorylation PhosphoSitePlus
S739 Phosphorylation PhosphoSitePlus
Y740 Phosphorylation PhosphoSitePlus
Y746 Phosphorylation PhosphoSitePlus
K756 Ubiquitination PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus
Y770 Phosphorylation PhosphoSitePlus
K771 Acetylation PhosphoSitePlus
T772 Phosphorylation PhosphoSitePlus
T782 Phosphorylation PhosphoSitePlus   UniProt 24275569
K786 Acetylation PhosphoSitePlus
K814 Ubiquitination PhosphoSitePlus
K823 Ubiquitination PhosphoSitePlus
K837 Ubiquitination PhosphoSitePlus
K856 Ubiquitination PhosphoSitePlus
K872 Ubiquitination PhosphoSitePlus
T881 Phosphorylation PhosphoSitePlus
Y885 Phosphorylation PhosphoSitePlus
Y890 Phosphorylation PhosphoSitePlus
K910 Ubiquitination PhosphoSitePlus
S970 Phosphorylation PhosphoSitePlus
T1002 Phosphorylation PhosphoSitePlus   UniProt 24275569
K1024 Ubiquitination PhosphoSitePlus
Y1106 Phosphorylation PhosphoSitePlus
Y1172 Phosphorylation PhosphoSitePlus
Y1178 Phosphorylation PhosphoSitePlus
T1249 Phosphorylation PhosphoSitePlus
T1269 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1271 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1276 Phosphorylation PhosphoSitePlus
S1279 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1284 Phosphorylation PhosphoSitePlus
Y1286 Phosphorylation PhosphoSitePlus
S1296 Phosphorylation PhosphoSitePlus
S1298 Phosphorylation PhosphoSitePlus
T1349 Phosphorylation PhosphoSitePlus
S1356 Phosphorylation PhosphoSitePlus
S1358 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K1392 Ubiquitination PhosphoSitePlus
Y1393 Phosphorylation PhosphoSitePlus
K1430 Ubiquitination PhosphoSitePlus
Y1435 Phosphorylation PhosphoSitePlus
Y1445 Phosphorylation PhosphoSitePlus
S1461 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1467 Acetylation PhosphoSitePlus
K1471 Acetylation PhosphoSitePlus
K1474 Acetylation PhosphoSitePlus
K1489 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation HPRD 19651622, 20166139, 19664994, ...20058876, 18212344
S24 Phosphorylation HPRD 20166139
S685 Phosphorylation HPRD 19651622, 20166139
S875 Phosphorylation HPRD 20068231
T1276 Phosphorylation HPRD 20068231
S1284 Phosphorylation HPRD 20068231
T1349 Phosphorylation HPRD 20166139
S1356 Phosphorylation HPRD 20166139
S1358 Phosphorylation HPRD 20166139


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S24 C24 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K77 E77 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K91 N91 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S195 Y195 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S373 F373 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S432 R432 Biomuta DOID:263 / kidney cancer [ cosmic ]
S591 F591 Biomuta DOID:1319 / brain cancer [ icgc ]
S591 Y591 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K608 N608 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K631 T631 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S685 L685 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T735 A735 Biomuta DOID:1612 / breast cancer [ icgc ]
T735 S735 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y746 C746 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y770 C770 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y770 N770 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K771 N771 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T772 I772 Biomuta DOID:1324 / lung cancer [ cosmic ]
K856 Q856 Biomuta DOID:363 / uterine cancer [ icgc ]
S1279 F1279 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1279 Y1279 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S1284 I1284 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y1445 C1445 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K1467 E1467 Biomuta DOID:9256 / colorectal cancer [ cosmic ]