iPTMnet Report for Q13563 (PKD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13563 / PKD2_HUMAN
Protein Name Polycystin-2
Gene Name Name: PKD2
Synonyms:TRPP2;
Organism Homo sapiens (Human)

PRO ID PR:Q13563
DAG View
PRO Name polycystin-2 (human)
Definition A polycystin-2 that is encoded in the genome of human.
Short Label hPKD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13563 (PKD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S74 Phosphorylation PhosphoSitePlus
S76 Phosphorylation P49840 (GSK3A) PhosphoSitePlus   RLIMS-P   Signor   UniProt 16551655
S80 Phosphorylation PhosphoSitePlus   UniProt 16551655
S125 Phosphorylation PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
R139 Methylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
S244 Phosphorylation RLIMS-P 17962809
S254 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
T260 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S263 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
N299 N-Glycosylation GlyGen   UniProt 28092368, 24190977
N305 N-Glycosylation GlyGen   UniProt 28092368, 24190977
S307 Phosphorylation PhosphoSitePlus
N328 N-Glycosylation GlyGen   UniProt 27768895, 27991905, 19139490, ...28092368
S330 O-Glycosylation GlyGen 35289036
N362 N-Glycosylation GlyGen   UniProt 27768895, 27991905, 28092368
T364 O-Glycosylation GlyGen 35289036
N375 N-Glycosylation GlyGen   UniProt 27768895, 27991905, 28092368
S408 Phosphorylation PhosphoSitePlus
T588 Phosphorylation PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus
K695 Ubiquitination PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
K735 Ubiquitination PhosphoSitePlus
T751 Phosphorylation PhosphoSitePlus
S801 Phosphorylation Q15139 (PRKD1) , Q9BZL6 (PRKD2) PhosphoSitePlus   Signor   UniProt 16551655, 20881056
S808 Phosphorylation PhosphoSitePlus
S812 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 21670214, 14742446, ...24275569, 16551655, 15692563
S829 Phosphorylation O14965 (AURKA) , P17612 (PRKACA) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 26269590, 21670214, 23390129
S852 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S858 Phosphorylation phospho.ELM 17287340
S944 Phosphorylation RLIMS-P 21670214
S949 Phosphorylation PhosphoSitePlus
T952 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S166 Phosphorylation HPRD 17081983
S254 Phosphorylation HPRD 17287340
T260 Phosphorylation HPRD 17287340
S263 Phosphorylation HPRD 17287340
S812 Phosphorylation HPRD 19651622
S852 Phosphorylation HPRD 17287340
S949 Phosphorylation HPRD 18077418


Q13563 (PKD2) as PTM Enzyme



Substrate Site Score Source PMID
Q9BZL6 (PRKD2) S876 phospho.ELM 11062248, 12058027


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S254 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S263 F263 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T364 A364 Biomuta DOID:4159 / skin cancer [ cosmic ]
S408 I408 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T751 A751 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T751 I751 Biomuta DOID:4159 / skin cancer [ cosmic ]
S812 F812 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S829 C829 Biomuta DOID:4159 / skin cancer [ cosmic ]
S858 P858 Biomuta DOID:363 / uterine cancer [ icgc ]
S858 T858 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S949 F949 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T952 A952 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]