iPTMnet Report for Q13523 (PRPF4B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13523 / PRP4B_HUMAN
Protein Name Serine/threonine-protein kinase PRP4 homolog
Gene Name Name: PRPF4B
Synonyms:KIAA0536,PRP4,PRP4H,PRP4K;
Organism Homo sapiens (Human)

PRO ID PR:Q13523
DAG View
PRO Name serine/threonine-protein kinase PRP4 homolog (human)
Definition A serine/threonine-protein kinase PRP4 that is encoded in the genome of human.
Short Label hPRPF4B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13523 (PRPF4B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
T6 Phosphorylation HPRD   PhosphoSitePlus 19007248
S8 Phosphorylation HPRD   PhosphoSitePlus 19007248
S20 O-Glycosylation GlyGen 30379171, 33214551, 28510447, ...34019948, 29351928
S20 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 15302935, 18452278, 19651622, 18669648, 19690332, 20068231
S23 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 15302935, 18452278, 19651622, 18669648, 19690332, 20068231
S32 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 17081983, ...15302935, 19691289, 18452278, 19651622, 18669648, 19690332, 20068231
S36 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 15302935, 18452278
S41 Phosphorylation PhosphoSitePlus
S87 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
S93 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
K99 Acetylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K117 Sumoylation PhosphoSitePlus
S131 Phosphorylation HPRD   PhosphoSitePlus   UniProt 17081983, 24275569
Y140 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 19415658, 18669648, ...18452278, 19690332, 20068231
S142 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 17081983, ...18452278, 18669648, 24275569, 19690332, 20068231
S144 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 17081983, ...18452278, 18669648, 19415658, 19690332, 20068231
T162 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus   UniProt 23186163
T167 Phosphorylation PhosphoSitePlus
K168 Acetylation PhosphoSitePlus
K170 Acetylation PhosphoSitePlus
K170 Sumoylation PhosphoSitePlus
K177 Acetylation PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
K200 Acetylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
K202 Acetylation PhosphoSitePlus
S239 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
S241 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
T243 Phosphorylation HPRD   PhosphoSitePlus 20068231
S248 Phosphorylation PhosphoSitePlus
S257 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 19651622, 18669648, ...24275569, 20068231
T259 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 20068231
S277 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 21406692, 23186163, ...17081983, 18767875, 15302935, 19664995, 19691289, 19651622, 18669648, 24275569, 18707149, 20166139, 17924679, 20068231, 18212344
S283 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 17081983, 20068231
S285 Phosphorylation PhosphoSitePlus
S292 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 19651622, ...18669648, 20166139, 20068231, 16964243
S294 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 21406692, 23186163, ...16964243, 18767875, 15302935, 19651622, 18669648, 20166139, 20068231, 17081983
S328 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 21406692, 17081983, ...20068231
S330 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
S335 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
S349 Phosphorylation HPRD   PhosphoSitePlus 20068231
S354 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 15302935, 20068231
S356 O-Glycosylation GlyGen 30379171, 33214551, 28510447, ...34019948, 29351928
S356 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 15302935, 20068231
K358 Acetylation PhosphoSitePlus
S366 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 19651622, 20068231, 17924679
S368 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 21406692, 23186163, ...17081983, 18767875, 15302935, 17322306, 20068231, 17924679
S381 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20068231
S383 Phosphorylation HPRD   PhosphoSitePlus 20068231
T385 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 17081983
S387 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 15302935, 17081983, ...20068231
S394 Phosphorylation HPRD   PhosphoSitePlus 20068231
S396 Phosphorylation HPRD   PhosphoSitePlus 20068231
S410 O-Glycosylation GlyGen 30379171
S410 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
S411 O-Glycosylation GlyGen 30379171
S411 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
T414 Phosphorylation PhosphoSitePlus
S427 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S431 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18767875, 15302935, 19651622, 18669648, 20068231
S437 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18767875, ...15302935, 19651622, 18669648, 20068231
T439 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20068231
S443 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S445 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S458 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S460 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S465 Phosphorylation PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
K505 Methylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
S509 Phosphorylation PhosphoSitePlus
S518 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18452278, 18669648, ...19690332, 20068231
S519 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231, ...18452278
S520 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231, ...18452278
K551 Acetylation PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
Y554 Phosphorylation HPRD   PhosphoSitePlus 20068231
S559 Phosphorylation HPRD 20068231
S562 Phosphorylation HPRD   PhosphoSitePlus 20068231
S565 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S568 Phosphorylation HPRD   PhosphoSitePlus 20068231
S569 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15302935, 18452278, 19651622, ...18669648, 20068231
S572 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231, 18452278
S573 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18452278
T574 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
T576 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 17081983, 18452278
S578 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 15302935, ...16565220, 19651622, 18669648, 18452278, 19690332, 20068231
S580 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 15302935, ...16565220, 19651622, 18669648, 18452278, 19690332, 20068231
S606 Phosphorylation PhosphoSitePlus
S622 Phosphorylation HPRD   PhosphoSitePlus 20068231
S623 Phosphorylation HPRD   PhosphoSitePlus 20068231
S636 Phosphorylation PhosphoSitePlus
Y643 Phosphorylation PhosphoSitePlus
S646 Phosphorylation PhosphoSitePlus
K656 Acetylation PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
K659 Ubiquitination PhosphoSitePlus
Y674 Phosphorylation PhosphoSitePlus
K685 Acetylation PhosphoSitePlus
K685 Ubiquitination PhosphoSitePlus
K717 Acetylation PhosphoSitePlus   UniProt 19608861
K727 Ubiquitination PhosphoSitePlus
K731 Ubiquitination PhosphoSitePlus
K737 Acetylation PhosphoSitePlus
K747 Acetylation PhosphoSitePlus
C750 Methylation IEDB 31844290
S794 Phosphorylation PhosphoSitePlus
K817 Ubiquitination PhosphoSitePlus
S837 Phosphorylation PhosphoSitePlus
S839 Phosphorylation PhosphoSitePlus
T847 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648, 20068231, ...18452278
Y849 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17016520, 21406692, 17389395, ...17081983, 18220336, 20058876, 19664995, 18452278, 18083107, 15951569, 18669648, 19901323, 24275569, 19651622, 15592455, 19415658, 20068231, 16497976
S852 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
Y855 Phosphorylation PhosphoSitePlus
K892 Ubiquitination PhosphoSitePlus
K905 Acetylation PhosphoSitePlus
K907 Acetylation PhosphoSitePlus


Q13523 (PRPF4B) as PTM Enzyme



Substrate Site Score Source PMID
P19419 (ELK1) T417 PhosphoSitePlus   Signor 10799319


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S87 F87 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S144 F144 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T162 I162 Biomuta DOID:1612 / breast cancer [ cosmic ]
S165 L165 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S165 P165 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K202 N202 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S241 F241 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
T259 I259 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S277 F277 Biomuta DOID:4159 / skin cancer [ cosmic ]
S381 P381 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S381 T381 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S383 L383 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S387 C387 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S411 F411 Biomuta DOID:4159 / skin cancer [ cosmic ]
S427 A427 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S427 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S467 F467 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S519 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S519 L519 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S562 F562 Biomuta DOID:3571 / liver cancer [ cosmic ]
S569 C569 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S569 I569 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S569 R569 Biomuta DOID:1319 / brain cancer [ cosmic ]
T574 A574 Biomuta DOID:363 / uterine cancer [ icgc ]
T574 M574 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S622 L622 Biomuta [ cosmic ]
S623 C623 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S636 F636 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
K727 N727 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C750 F750 Biomuta DOID:3571 / liver cancer [ cosmic ]
S837 P837 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y849 S849 Biomuta DOID:4159 / skin cancer [ cosmic ]