iPTMnet Report for Q13470 (TNK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13470 / TNK1_HUMAN
Protein Name Non-receptor tyrosine-protein kinase TNK1
Gene Name Name: TNK1
Organism Homo sapiens (Human)

PRO ID PR:Q13470
DAG View
PRO Name non-receptor tyrosine-protein kinase TNK1 (human)
Definition A non-receptor tyrosine-protein kinase TNK1 that is encoded in the genome of human.
Short Label hTNK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13470 (TNK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S60 Phosphorylation PhosphoSitePlus   UniProt 18691976
S68 Phosphorylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
Y77 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
S96 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K108 Ubiquitination PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
T209 Phosphorylation PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
Y235 Phosphorylation PhosphoSitePlus
T248 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
T258 Phosphorylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
Y277 Phosphorylation PhosphoSitePlus
Y287 Phosphorylation PhosphoSitePlus
Y353 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
S411 Phosphorylation UniProt 18691976, 19369195
S468 Phosphorylation PhosphoSitePlus
K475 Methylation PhosphoSitePlus
S500 Phosphorylation PhosphoSitePlus
S502 Phosphorylation O14757 (CHEK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 23186163, ...17081983, 19369195, 18669648, 34504101, 21851590, 20068231
S505 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S508 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T514 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 17081983, ...20068231
S518 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S519 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S546 Phosphorylation PhosphoSitePlus
S550 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S553 Phosphorylation PhosphoSitePlus
K563 Ubiquitination PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
S582 Phosphorylation PhosphoSitePlus   UniProt 18691976
S587 Phosphorylation PhosphoSitePlus
T612 Phosphorylation PhosphoSitePlus
Y651 Phosphorylation PhosphoSitePlus
S659 Phosphorylation PhosphoSitePlus
Y661 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Site PTM Type PTM Enzyme Score Source PMID
S60 Phosphorylation HPRD 18691976
S68 Phosphorylation HPRD 20068231
S94 Phosphorylation HPRD 18691976
S96 Phosphorylation HPRD 18691976, 18669648
S255 Phosphorylation HPRD 18691976
Y277 Phosphorylation HPRD 18691976
S411 Phosphorylation HPRD   PhosphoSitePlus 18691976
K418 Ubiquitination PhosphoSitePlus
S463 Phosphorylation HPRD 18691976
S497 Phosphorylation HPRD 18691976, 16964243, 19664994, ...19651622, 18669648, 20068231
S500 Phosphorylation HPRD 18669648
S503 Phosphorylation HPRD 18669648
T509 Phosphorylation HPRD 18691976, 18669648, 17081983, ...20068231
S513 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983, 20068231
S514 Phosphorylation HPRD 18691976, 17081983, 19664994, ...19651622, 18669648, 20068231
S538 Phosphorylation HPRD 18691976
S545 Phosphorylation HPRD 18669648
S577 Phosphorylation HPRD 18691976, 20068231
S582 Phosphorylation HPRD 20068231
Y656 Phosphorylation HPRD 18691976, 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13470 (TNK1) S502 P27348 (YWHAQ) increased_association eFIP 34504101


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S94 L94 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S96 I96 Biomuta DOID:4362 / cervical cancer [ icgc ]
S411 N411 Biomuta DOID:9256 / colorectal cancer [ icgc ]