iPTMnet Report for Q13416 (ORC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13416 / ORC2_HUMAN
Protein Name Origin recognition complex subunit 2
Gene Name Name: ORC2
Synonyms:ORC2L;
Organism Homo sapiens (Human)

PRO ID PR:Q13416
DAG View
PRO Name origin recognition complex subunit 2 (human)
Definition An origin recognition complex subunit 2 that is encoded in the genome of human.
Short Label hORC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13416 (ORC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K47 Acetylation PhosphoSitePlus
Y70 Phosphorylation PhosphoSitePlus
S81 O-Glycosylation GlyGen 30379171, 36240223
Y95 Phosphorylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
K105 Acetylation PhosphoSitePlus
S111 O-Glycosylation GlyGen 30379171, 36240223
S111 Phosphorylation PhosphoSitePlus
T116 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22334659, 23186163, 11931757, ...24732362, 18669648, 20068231
T116 Phosphorylation P24941 (CDK2) PhosphoSitePlus   Signor 11931757, 22334659
S122 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S124 Phosphorylation PhosphoSitePlus
K126 Sumoylation PhosphoSitePlus
S138 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
K147 Acetylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S175 Phosphorylation HPRD 17081983
S177 Phosphorylation HPRD 17081983
S179 Phosphorylation HPRD 17081983
S181 Phosphorylation HPRD 17081983
S188 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 17081983, 21947279
S188 Phosphorylation P53350 (PLK1) PhosphoSitePlus 21947279
T202 Phosphorylation HPRD 17081983
S219 Phosphorylation PhosphoSitePlus
T226 Phosphorylation HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19413330, 22334659, 23186163, ...11931757, 19664995, 24732362, 20068231
T226 Phosphorylation P24941 (CDK2) PhosphoSitePlus   Signor 11931757, 22334659
S228 Phosphorylation HPRD   PhosphoSitePlus 20068231
K235 Ubiquitination PhosphoSitePlus
T236 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
Y243 Phosphorylation PhosphoSitePlus
S248 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S249 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
T258 Phosphorylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
S280 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18452278
S282 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
S528 Phosphorylation HPRD   PhosphoSitePlus 20068231
T531 Phosphorylation HPRD   PhosphoSitePlus 20068231
K549 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K47 Q47 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S81 L81 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y95 F95 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K105 E105 Biomuta DOID:263 / kidney cancer [ cosmic ]
S111 L111 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S124 R124 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S188 L188 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S248 I248 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S280 F280 Biomuta [ cosmic ]
S280 P280 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S528 C528 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]