iPTMnet Report for Q13409 (DYNC1I2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13409 / DC1I2_HUMAN
Protein Name Cytoplasmic dynein 1 intermediate chain 2
Gene Name Name: DYNC1I2
Synonyms:DNCI2,DNCIC2;
Organism Homo sapiens (Human)

PRO ID PR:Q13409
DAG View
PRO Name cytoplasmic dynein 1 intermediate chain 2 (human)
Definition A cytoplasmic dynein 1 intermediate chain 2 that is encoded in the genome of human.
Short Label hDYNC1I2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13409 (DYNC1I2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
S2 Phosphorylation PhosphoSitePlus
K8 Acetylation PhosphoSitePlus
K8 Ubiquitination PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus   UniProt 23186163
S73 Phosphorylation phospho.ELM   UniProt 18669648, 20068231
W81 Phosphorylation UniProt 19690332
P84 Phosphorylation UniProt 24275569
S87 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus 19767751, 18669648, 22028470
S89 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S90 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
S94 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17287340
T95 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S97 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 18669648
S101 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17525332
S104 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
K137 Ubiquitination PhosphoSitePlus
T160 O-Glycosylation GlyGen 23301498, 35008409, 34725712, ...29351928, 34019948, 28510447, 34229054
T162 Phosphorylation PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
T209 Phosphorylation PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
R269 Methylation PhosphoSitePlus
C331 Methylation IEDB 31844290
C408 Methylation IEDB 31844290
K427 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T70 Phosphorylation HPRD 20068231
S73 Phosphorylation HPRD 20068231
S78 Phosphorylation HPRD 20068231
Y80 Phosphorylation HPRD 20068231
S87 Phosphorylation HPRD 20068231
S89 Phosphorylation HPRD 20068231
S90 Phosphorylation HPRD 20068231
S92 Phosphorylation HPRD 19413330, 20068231
S94 Phosphorylation HPRD 19413330, 18669648, 17287340, ...20068231
T95 Phosphorylation HPRD 19413330, 18669648, 18491316
S97 Phosphorylation HPRD 18669648
S101 Phosphorylation HPRD 19413330
S104 Phosphorylation HPRD 19413330
T162 Phosphorylation HPRD 19413330
S248 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T70 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S66 Phosphorylation PhosphoSitePlus
T70 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K8 Q8 Biomuta DOID:1540 / parathyroid carcinoma [ cosmic ]
S95 N95 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S98 C98 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S101 N101 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S104 C104 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K137 T137 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K191 N191 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S219 F219 Biomuta DOID:4159 / skin cancer [ cosmic ]
S238 A238 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S238 C238 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
R269 * Biomuta DOID:3571 / liver cancer [ cosmic ]
R269 Q269 Biomuta DOID:363 / uterine cancer [ icgc ]