iPTMnet Report for Q13310 (PABPC4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13310 / PABP4_HUMAN
Protein Name Polyadenylate-binding protein 4
Gene Name Name: PABPC4
Synonyms:APP1,PABP4;
Organism Homo sapiens (Human)

PRO ID PR:Q13310
DAG View
PRO Name polyadenylate-binding protein 4 (human)
Definition A polyadenylate-binding protein 4 that is encoded in the genome of human.
Short Label hPABPC4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13310 (PABPC4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S32 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
Y54 Phosphorylation PhosphoSitePlus
Y56 Phosphorylation PhosphoSitePlus
T71 Phosphorylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
S96 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K104 Acetylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K108 Acetylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
S109 Phosphorylation IEDB 35494241
K113 Ubiquitination PhosphoSitePlus
Y116 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
Y140 Phosphorylation PhosphoSitePlus   UniProt 15592455
K157 Ubiquitination PhosphoSitePlus
R166 Methylation PhosphoSitePlus
K167 Sumoylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
R179 Methylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K188 Methylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus
Y194 Phosphorylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus   UniProt 23186163
K208 Ubiquitination PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
Y291 Phosphorylation PhosphoSitePlus
Y297 Phosphorylation PhosphoSitePlus
K299 Acetylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
T304 Phosphorylation PhosphoSitePlus   UniProt 23186163
K309 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S319 Phosphorylation PhosphoSitePlus   UniProt 23186163
T321 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
Y364 Phosphorylation PhosphoSitePlus   UniProt 23186163
K375 Methylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
T379 Phosphorylation PhosphoSitePlus
Y382 Phosphorylation PhosphoSitePlus
R385 Methylation PhosphoSitePlus
R419 Methylation PhosphoSitePlus   UniProt 24129315
R432 Methylation PhosphoSitePlus   UniProt 24129315
R436 Methylation PhosphoSitePlus   UniProt 24129315
R442 Methylation PhosphoSitePlus
R454 Methylation PhosphoSitePlus   UniProt 24129315
R459 Methylation PhosphoSitePlus
R463 Methylation PhosphoSitePlus
S496 Methylation UniProt 24129315
R509 Methylation PhosphoSitePlus
R518 Methylation PhosphoSitePlus
K524 Methylation PhosphoSitePlus
R530 Methylation PhosphoSitePlus   UniProt 24129315
S531 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S584 Phosphorylation PhosphoSitePlus   UniProt 23186163
S600 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
T643 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30397120, 30379171, 30059200, 35254053, 34019948, 31492838, 20305658, 32119511, 30620550, 22121020, 31373491
S644 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30397120, 30379171, 30059200, 35254053, 34019948, 31492838, 20305658, 32119511, 30620550, 22121020, 31373491
S644 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S96 Phosphorylation HPRD 18669648
Y140 Phosphorylation HPRD 15592455
T191 Phosphorylation HPRD 18452278
Y194 Phosphorylation HPRD 18452278
Y297 Phosphorylation HPRD 20068231
S315 Phosphorylation HPRD 20068231
S531 Phosphorylation HPRD 18669648
S611 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
R442 Methylation PhosphoSitePlus
R454 Methylation PhosphoSitePlus
R459 Methylation PhosphoSitePlus
R463 Methylation PhosphoSitePlus
R475 Methylation PhosphoSitePlus
R483 Methylation PhosphoSitePlus
R496 Methylation PhosphoSitePlus
R505 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
R475 Methylation PhosphoSitePlus
R483 Methylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
R491 Methylation PhosphoSitePlus
R525 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K78 N78 Biomuta [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, cosmic, cosmic, cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ]
K108 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S109 Y109 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K188 T188 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S206 N206 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S212 R212 Biomuta DOID:363 / uterine cancer [ icgc ]
Y291 H291 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T321 A321 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S341 P341 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T379 A379 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y382 C382 Biomuta DOID:4362 / cervical cancer [ cosmic ]
R385 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R385 H385 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R436 C436 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R436 H436 Biomuta [ cosmic ]
R442 K442 Biomuta DOID:4159 / skin cancer [ cosmic ]
R442 I442 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R454 C454 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
R459 C459 Biomuta DOID:4159 / skin cancer [ cosmic ]
R459 H459 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R463 C463 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R463 H463 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
R475 C475 Biomuta DOID:5041 / esophageal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S486 F486 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R491 H491 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ icgc ]
R496 C496 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R505 Q505 Biomuta DOID:4159 / skin cancer [ cosmic ]
R505 W505 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
R509 C509 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R518 W518 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R518 Q518 Biomuta DOID:4159 / skin cancer [ cosmic ]
R525 C525 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R530 C530 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]