iPTMnet Report for Q13243 (SRSF5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13243 / SRSF5_HUMAN
Protein Name Serine/arginine-rich splicing factor 5
Gene Name Name: SRSF5
Synonyms:HRS,SFRS5,SRP40;
Organism Homo sapiens (Human)

PRO ID PR:Q13243
DAG View
PRO Name serine/arginine-rich splicing factor 5 (human)
Definition A serine/arginine-rich splicing factor 5 that is encoded in the genome of human.
Short Label hSRSF5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13243 (SRSF5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R5 Methylation PhosphoSitePlus
R10 Methylation PhosphoSitePlus
K25 Methylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
R48 Methylation PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
C63 S-Nitrosylation dbSNO 26338901
R73 Methylation PhosphoSitePlus
R75 Methylation PhosphoSitePlus
S86 Phosphorylation P31751 (AKT2) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 15684423, 23186163, 23536862
R88 Methylation PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
R92 Methylation PhosphoSitePlus
R93 Methylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
S117 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S120 Phosphorylation PhosphoSitePlus
K125 Acetylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
T135 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
Y154 Phosphorylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K163 Acetylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K167 Acetylation PhosphoSitePlus   UniProt 19608861
K167 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
S225 O-Glycosylation GlyGen 33214551, 28510447, 34019948, ...34229054, 33465208
S227 Phosphorylation PhosphoSitePlus   UniProt 21406692
S229 O-Glycosylation GlyGen 33465208
S229 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S231 O-Glycosylation GlyGen 33465208
S231 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935
S233 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 21406692
S244 Phosphorylation PhosphoSitePlus
S245 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
S250 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 33849617, 17081983
S253 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 15302935, 17081983, ...24275569
Site PTM Type PTM Enzyme Score Source PMID
S117 Phosphorylation HPRD 18452278
S211 Phosphorylation HPRD 20068231
S213 Phosphorylation HPRD 20068231
S215 Phosphorylation HPRD 20068231
S227 Phosphorylation HPRD 19651622, 17081983, 20068231
S229 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S231 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S233 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S250 Phosphorylation HPRD 19651622, 17081983, 20068231
S253 Phosphorylation HPRD 19651622, 17081983
Site PTM Type PTM Enzyme Score Source PMID
S91 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R48 K48 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R75 L75 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R88 H88 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R92 H92 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
R92 C92 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R92 S92 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S117 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
S153 C153 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K158 N158 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S211 C211 Biomuta DOID:1324 / lung cancer [ cosmic ]
S253 Y253 Biomuta DOID:1319 / brain cancer [ icgc ]