iPTMnet Report for Q13042 (CDC16)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13042 / CDC16_HUMAN
Protein Name Cell division cycle protein 16 homolog
Gene Name Name: CDC16
Synonyms:ANAPC6;
Organism Homo sapiens (Human)

PRO ID PR:Q13042
DAG View
PRO Name cell division cycle protein 16 homolog (human)
Definition A cell division cycle protein 16 that is encoded in the genome of human.
Short Label hCDC16
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13042 (CDC16) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T50 Phosphorylation PhosphoSitePlus
Y53 Phosphorylation PhosphoSitePlus
C72 Methylation IEDB 31844290
K101 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
S112 Phosphorylation P06493 (CDK1) , P53350 (PLK1) phospho.ELM   PhosphoSitePlus   UniProt 14657031, 22067460
K115 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
T327 Phosphorylation PhosphoSitePlus
T328 Phosphorylation PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus
T420 Phosphorylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
T440 Phosphorylation PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
S490 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14657031
C544 Methylation IEDB 31844290
K553 Ubiquitination PhosphoSitePlus
K556 Ubiquitination PhosphoSitePlus
S560 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18691976, 23186163, 16964243, ...22067460, 18220336, 14657031, 18669648, 20068231
K572 Ubiquitination PhosphoSitePlus
T581 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 16964243, ...22067460, 14657031, 19690332, 20068231
S586 Phosphorylation PhosphoSitePlus
T589 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S595 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14657031
T599 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14657031
S607 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S614 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
Site PTM Type PTM Enzyme Score Source PMID
S560 Phosphorylation HPRD 18691976, 19664995, 16565220, ...19651622, 18669648, 18452278, 20068231
T581 Phosphorylation HPRD 18691976, 16964243, 20068231, ...16565220


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8NHZ8 (CDC26) T7 Q13042 (CDC16) unknown eFIP 25723520


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O60566 (hBUB1B) Interaction PR:Q13042 (hCDC16) PRO 11030144
PR:Q13042 (hCDC16) Interaction PR:O60566 (hBUB1B) PRO 11030144


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K106 N106 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K129 T129 Biomuta DOID:4159 / skin cancer [ cosmic ]
K138 N138 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic, icgc ]
K260 R260 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T420 A420 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S490 R490 Biomuta DOID:4159 / skin cancer [ cosmic ]
C544 Y544 Biomuta DOID:363 / uterine cancer [ icgc ]
K553 E553 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T581 M581 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S595 F595 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]