iPTMnet Report for Q12996 (CSTF3)
Protein Information
UniProt AC / UniProt ID | Q12996 / CSTF3_HUMAN |
Protein Name | Cleavage stimulation factor subunit 3 |
Gene Name | Name: CSTF3 |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q12996 |
PRO Name | cleavage stimulation factor subunit 3 (human) |
Definition | A cleavage stimulation factor subunit 3 that is encoded in the genome of human. |
Short Label | hCSTF3 |
Category | organism-gene |
Q12996 (CSTF3) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S2 | Acetylation | score1 | UniProt | 19413330, 22223895 | ||
S2 | Phosphorylation | score1 | PhosphoSitePlus | |||
K17 | Ubiquitination | score1 | PhosphoSitePlus | |||
K49 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y54 | Phosphorylation | score1 | PhosphoSitePlus | |||
S63 | Phosphorylation | score1 | PhosphoSitePlus | |||
S64 | Phosphorylation | score1 | PhosphoSitePlus | |||
K86 | Ubiquitination | score1 | PhosphoSitePlus | |||
K94 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y104 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y107 | Phosphorylation | score1 | PhosphoSitePlus | |||
K114 | Acetylation | score1 | PhosphoSitePlus | |||
Y126 | Phosphorylation | score1 | PhosphoSitePlus | |||
S139 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y140 | Phosphorylation | score1 | PhosphoSitePlus | |||
K192 | Ubiquitination | score1 | PhosphoSitePlus | |||
K228 | Ubiquitination | score1 | PhosphoSitePlus | |||
S261 | Phosphorylation | score1 | PhosphoSitePlus | |||
T266 | Phosphorylation | score1 | PhosphoSitePlus | |||
T273 | Phosphorylation | score1 | PhosphoSitePlus | |||
K274 | Ubiquitination | score1 | PhosphoSitePlus | |||
C283 | Methylation | score1 | IEDB | 31844290 | ||
S321 | Phosphorylation | score1 | PhosphoSitePlus | |||
K355 | Acetylation | score1 | PhosphoSitePlus | |||
K358 | Acetylation | score1 | PhosphoSitePlus | |||
Y450 | Phosphorylation | score1 | IEDB | 32357974 | ||
K529 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y534 | Phosphorylation | score1 | PhosphoSitePlus | |||
K542 | Acetylation | score1 | PhosphoSitePlus | |||
Y546 | Phosphorylation | score1 | PhosphoSitePlus | |||
K547 | Acetylation | score1 | PhosphoSitePlus | |||
S566 | Phosphorylation | score1 | PhosphoSitePlus | |||
K682 | Ubiquitination | score1 | PhosphoSitePlus | |||
S691 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18691976, 21406692, 23186163, ... | ||
Y708 | Phosphorylation | score1 | PhosphoSitePlus |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | Q00403 (GTF2B) | S65 | Q12996 (CSTF3) | unknown | eFIP | 20226668 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
Y104 | F104 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] | |
T273 | K273 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
K529 | R529 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S691 | L691 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
S691 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] |