iPTMnet Report for Q12948 (FOXC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12948 / FOXC1_HUMAN
Protein Name Forkhead box protein C1
Gene Name Name: FOXC1
Synonyms:FKHL7,FREAC3;
Organism Homo sapiens (Human)

PRO ID PR:Q12948
DAG View
PRO Name forkhead box protein C1 (human)
Definition A forkhead box protein C1 that is encoded in the genome of human.
Short Label hFOXC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12948 (FOXC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S12 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
R62 Methylation PhosphoSitePlus
T68 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S125 Phosphorylation PhosphoSitePlus
K138 Sumoylation PhosphoSitePlus
Y159 Phosphorylation PhosphoSitePlus
K227 Sumoylation PhosphoSitePlus
T228 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
T232 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S235 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 19413330, ...20068231
S241 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18691976, 18212344, ...18669648, 20068231
S248 Phosphorylation HPRD 20068231
S259 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus   UniProt 16492674
S320 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 30379171, 31492838, 30620550, 34019948, 35289036, 35254053
S320 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 20068231, ...18452278
S323 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 30379171, 31492838, 30620550, 34019948, 35289036, 35254053
S323 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S329 Phosphorylation HPRD 20068231
S330 Phosphorylation PhosphoSitePlus
S335 O-Glycosylation GlyGen 34846842
S335 Phosphorylation PhosphoSitePlus
S339 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 30379171, 31492838, 30620550, 34019948, 35289036, 35254053
S339 Phosphorylation HPRD 20068231
S340 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 30379171, 31492838, 30620550, 34019948, 35289036, 35254053
S521 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S543 Phosphorylation PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S125 G125 Biomuta DOID:1612 / breast cancer [ cosmic ]
S125 N125 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K138 N138 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y159 F159 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y159 H159 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S272 N272 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S340 W340 Biomuta DOID:1324 / lung cancer [ cosmic ]
S521 F521 Biomuta DOID:3571 / liver cancer [ cosmic ]
S521 C521 Biomuta DOID:1612 / breast cancer [ cosmic ]
S543 F543 Biomuta DOID:1612 / breast cancer [ cosmic ]