iPTMnet Report for Q12874 (SF3A3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12874 / SF3A3_HUMAN
Protein Name Splicing factor 3A subunit 3
Gene Name Name: SF3A3
Synonyms:SAP61;
Organism Homo sapiens (Human)

PRO ID PR:Q12874
DAG View
PRO Name splicing factor 3A subunit 3 (human)
Definition A splicing factor 3A subunit 3 that is encoded in the genome of human.
Short Label hSF3A3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12874 (SF3A3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378, 22223895
K24 Acetylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
S31 O-Glycosylation GlyGen 30379171
T32 Phosphorylation PhosphoSitePlus
T43 Phosphorylation PhosphoSitePlus
R49 Methylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus   UniProt 23186163
R58 Methylation PhosphoSitePlus
Y61 Phosphorylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K92 Acetylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
C103 Methylation IEDB 31844290
K115 Ubiquitination PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus   UniProt 23186163
T131 Phosphorylation PhosphoSitePlus
C145 Methylation IEDB 31844290
K148 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
Y160 Phosphorylation IEDB 32387766
K201 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K219 Acetylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
T277 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
K291 Ubiquitination PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
S295 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19664994, 23186163
S299 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
K303 Ubiquitination PhosphoSitePlus
T352 Phosphorylation HPRD   PhosphoSitePlus 17081983
S365 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18452278, ...18669648, 19690332, 20068231
S367 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18452278, ...18669648, 19690332, 20068231
S369 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18452278, ...18669648, 19690332, 20068231
Y378 Phosphorylation HPRD 17081983
K390 Ubiquitination PhosphoSitePlus
C411 Methylation IEDB 31844290
Y414 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15592455
Y416 Phosphorylation PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
R470 Methylation PhosphoSitePlus
T475 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y479 Phosphorylation PhosphoSitePlus
S482 Phosphorylation PhosphoSitePlus
K489 Acetylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
T491 Phosphorylation HPRD   PhosphoSitePlus 19562805
Y492 Phosphorylation PhosphoSitePlus
K496 Methylation PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R58 G58 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K92 N92 Biomuta DOID:1612 / breast cancer [ cosmic ]
C145 * Biomuta DOID:263 / kidney cancer [ cosmic ]
C145 Y145 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K212 E212 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S292 A292 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S367 R367 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R470 L470 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]