iPTMnet Report for Q12866 (MERTK)
Protein Information
UniProt AC / UniProt ID | Q12866 / MERTK_HUMAN |
Protein Name | Tyrosine-protein kinase Mer precursor |
Gene Name | Name: MERTK Synonyms:MER; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q12866 |
PRO Name | tyrosine-protein kinase Mer (human) |
Definition | A tyrosine-protein kinase Mer that is encoded in the genome of human. |
Short Label | hMERTK |
Category | organism-gene |
Q12866 (MERTK) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T45 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
T84 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
N114 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
N170 | N-Glycosylation | score1 | GlyGen | 23090970, 29391424, 24190977 | ||
N207 | N-Glycosylation | score1 | GlyGen | 23090970, 29741879, 29391424 | ||
N266 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
N316 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
N442 | N-Glycosylation | score2 | GlyGen UniProt | 16335952, 23090970, 29671580, ... | ||
N454 | N-Glycosylation | score1 | GlyGen | 29391424, 24190977 | ||
T458 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 19664995 | ||
S543 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
Y549 | Phosphorylation | score1 | PhosphoSitePlus | |||
K552 | Ubiquitination | score1 | PhosphoSitePlus | |||
K591 | Ubiquitination | score1 | PhosphoSitePlus | |||
S613 | Phosphorylation | score1 | PhosphoSitePlus | |||
K622 | Ubiquitination | score1 | PhosphoSitePlus | |||
N625 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
S645 | Phosphorylation | score1 | PhosphoSitePlus | |||
T699 | Phosphorylation | score1 | PhosphoSitePlus | |||
S745 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y749 | Phosphorylation | Q12866 (MERTK) | score3 | HPRD neXtProt phospho.ELM PhosphoSitePlus Signor UniProt | 8702477 | |
S750 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y753 | Phosphorylation | Q12866 (MERTK) | score4 | HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 8702477, 33119085 | |
Y754 | Phosphorylation | Q12866 (MERTK) | score4 | HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 8702477, 33119085 | |
K761 | Ubiquitination | score1 | PhosphoSitePlus | |||
K765 | Ubiquitination | score1 | PhosphoSitePlus | |||
R775 | Methylation | score1 | PhosphoSitePlus | |||
K856 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y872 | Phosphorylation | Q12866 (MERTK) | score2 | neXtProt | 18039660 | |
K923 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y929 | Phosphorylation | score1 | PhosphoSitePlus | |||
S935 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 |
Q12866 (MERTK) as PTM Enzyme
Substrate | Site | Score | Source | PMID | |
---|---|---|---|---|---|
Q12866 (MERTK) | Y749 | score3 | HPRD neXtProt PhosphoSitePlus Signor UniProt | 8702477 | |
Q12866 (MERTK) | Y753 | score3 | HPRD neXtProt PhosphoSitePlus Signor UniProt | 8702477 | |
Q12866 (MERTK) | Y754 | score3 | HPRD neXtProt PhosphoSitePlus Signor UniProt | 8702477 | |
Q12866 (MERTK) | Y872 | score2 | neXtProt | 18039660 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T84 | A84 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
N454 | D454 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
N454 | S454 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] | |
S543 | F543 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
K552 | N552 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
K591 | N591 | Biomuta | DOID:3565 / meningioma [ cosmic ] | |
S613 | F613 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K622 | N622 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
Y749 | C749 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
R775 | * | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
K923 | R923 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S935 | N935 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |