iPTMnet Report for Q12846 (STX4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12846 / STX4_HUMAN
Protein Name Syntaxin-4
Gene Name Name: STX4
Synonyms:STX4A;
Organism Homo sapiens (Human)

PRO ID PR:Q12846
DAG View
PRO Name syntaxin-4 (human)
Definition A syntaxin-4 that is encoded in the genome of human.
Short Label hSTX4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12846 (STX4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
S14 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 24275569
S15 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 24275569
T31 Phosphorylation PhosphoSitePlus   UniProt 23186163
S36 Phosphorylation PhosphoSitePlus   UniProt 23186163
K44 Ubiquitination PhosphoSitePlus
T51 Phosphorylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
T72 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus   RLIMS-P 29896202
K80 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus
S117 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T120 Phosphorylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
T125 Phosphorylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
Y251 Phosphorylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation HPRD 19651622, 18669648, 20068231
S15 Phosphorylation HPRD 19651622, 18669648, 20068231
S36 Phosphorylation HPRD 20068231
Y115 Phosphorylation HPRD 17389395
S117 Phosphorylation HPRD 20166139, 18578522, 18669648, ...20068231
S208 Phosphorylation HPRD 20166139
Y251 Phosphorylation HPRD 18578522, 17389395, 18707149


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049374 (hSTX4/PhosRes+) p PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O00161 (SNAP23) S161 Q12846 (STX4) inhibited_association eFIP 12930825
Phosphorylation O00186 (STXBP3) Y521 Q12846 (STX4) unknown eFIP 17916632
Phosphorylation O00186 (STXBP3) Y219 Q12846 (STX4) unknown eFIP 21444687
Phosphorylation Q6ZWJ1 (STXBP4) S99 Q12846 (STX4) unknown eFIP 24705589
Phosphorylation Q6ZWJ1 (STXBP4) S99 Q12846 (STX4) unknown eFIP 15753124


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S15 P15 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S15 L15 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1540 / parathyroid carcinoma [ cosmic ]
K54 E54 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K58 E58 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K80 T80 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K124 I124 Biomuta DOID:3571 / liver cancer [ cosmic ]