iPTMnet Report for Q12834 (CDC20)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12834 / CDC20_HUMAN
Protein Name Cell division cycle protein 20 homolog
Gene Name Name: CDC20
Organism Homo sapiens (Human)

PRO ID PR:Q12834
DAG View
PRO Name cell division cycle protein 20 homolog (human)
Definition A cell division cycle protein 20 homolog that is encoded in the genome of human.
Short Label hCDC20
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12834 (CDC20) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
K33 Methylation PhosphoSitePlus
S41 Phosphorylation PR:O43683 (hBUB1) , O43683 (BUB1) HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19413330, 23186163, 26960431, ...15525512, 22067460, 18669648
S49 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
T55 Phosphorylation PhosphoSitePlus   RLIMS-P 26960431
T59 Phosphorylation PhosphoSitePlus   RLIMS-P 26960431
K62 Ubiquitination PhosphoSitePlus
S63 Phosphorylation HPRD 18767875
S64 Phosphorylation HPRD 18767875
K66 Acetylation UniProt 22014574
K66 Ubiquitination PhosphoSitePlus
T69 Phosphorylation PhosphoSitePlus
T70 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 26714015, 14657031, ...18767875, 22067460, 26960431, 26912231
S72 Phosphorylation PR:O43683 (hBUB1) , O43683 (BUB1) HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15525512, 26912231, 18767875, ...22067460
K73 Ubiquitination PhosphoSitePlus
Y79 Phosphorylation HPRD   PhosphoSitePlus 18767875
S84 Phosphorylation PhosphoSitePlus   RLIMS-P 26912231
S92 Phosphorylation O43683 (BUB1) , PR:O43683 (hBUB1) HPRD   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15525512, 26912231
S96 Phosphorylation RLIMS-P 26912231
K97 Ubiquitination PhosphoSitePlus
T106 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 14657031, 26960431, 26912231, ...22067460
K109 Sumoylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
Y152 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PR:O43683 (hBUB1) , O43683 (BUB1) HPRD   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15525512, 26912231, 18995837
K155 Ubiquitination PhosphoSitePlus
T157 Phosphorylation O43683 (BUB1) , PR:O43683 (hBUB1) HPRD   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15525512, 26960431, 26912231
S160 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PR:O43683 (hBUB1) , O43683 (BUB1) HPRD   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15525512, 26912231
T164 Phosphorylation PhosphoSitePlus
C165 Methylation IEDB 31844290
S170 Phosphorylation P53350 (PLK1) PhosphoSitePlus   RLIMS-P+ 23643811
R174 Methylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
C403 Methylation IEDB 31844290
K435 Ubiquitination PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
T457 Phosphorylation PhosphoSitePlus
T466 Phosphorylation PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus   UniProt 21926987
S487 Phosphorylation RLIMS-P 26960431
K490 Sumoylation PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus   UniProt 21926987
S492 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000035371 (hCDC20/Phos:1) pS41,pS72,pS92,pS153,pT157,pS161 PR:O43683 (hBUB1) PRO 15525512
PR:000046658 (hCDC20/UbiqLys+) ub PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q5XUX0 (FBXO31) S278 Q12834 (CDC20) inhibited_association eFIP 29343641
Phosphorylation Q9Y6D9 (MAD1L1) T716 Q12834 (CDC20) increased_association eFIP 28072388
Phosphorylation Q9Y6D9 (MAD1L1) T716 Q12834 (CDC20) increased_association eFIP 29868582


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000035369 (hCDC20/PhosRes-) Interaction PR:O60566 (hBUB1B) PRO 15525512
PR:000035369 (hCDC20/PhosRes-) Interaction PR:Q13257 (hMAD2L1) PRO 15525512
PR:000035371 (hCDC20/Phos:1) Interaction PR:O60566 (hBUB1B) PRO 15525512
PR:000035371 (hCDC20/Phos:1) Interaction PR:Q13257 (hMAD2L1) PRO 15525512
PR:000035428 (hBUB1B/Phos:2) Interaction PR:Q12834 (hCDC20) PRO 11030144
PR:000035442 (hCDC20/Phos:3) decreased Interaction PR:O60566 (hBUB1B) PRO 22566641
PR:O43684 (hBUB3) Interaction PR:Q12834 (hCDC20) PRO
PR:O60566 (hBUB1B) Interaction PR:Q12834 (hCDC20) PRO 11030144, 20624902
PR:P33981 (hTTK) Interaction PR:Q12834 (hCDC20) PRO
PR:Q12834 (hCDC20) Interaction PR:Q13257 (hMAD2L1) PRO 20624902
PR:Q12834 (hCDC20) Interaction PR:O60566 (hBUB1B) PRO 11030144, 20624902
PR:Q13257 (hMAD2L1) Interaction PR:Q12834 (hCDC20) PRO 20624902
PR:Q96GD4 (hAURKB) Interaction PR:Q12834 (hCDC20) PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T106 A106 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K114 R114 Biomuta DOID:1324 / lung cancer [ cosmic ]
S134 R134 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K149 R149 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T164 P164 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
T164 N164 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R174 H174 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K259 T259 Biomuta DOID:363 / uterine cancer [ icgc ]