iPTMnet Report for Q12778 (FOXO1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12778 / FOXO1_HUMAN
Protein Name Forkhead box protein O1
Gene Name Name: FOXO1
Synonyms:FKHR;
Organism Homo sapiens (Human)

PRO ID PR:Q12778
DAG View
PRO Name forkhead box protein O1 (human)
Definition A forkhead box protein O1 that is encoded in the genome of human.
Short Label hFOXO1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12778 (FOXO1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation PhosphoSitePlus
T24 Phosphorylation P31751 (AKT2) , P31749 (AKT1) , P11309-2 (PIM1) , PR:P31749 (hAKT1) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22384145, 11237865, 16157701, ...28675664, 19887561, 11311120, 30559384, 10377430, 25603236, 22928011, 18226221, 16203862, 28993609, 24112473, 21298325, 21177856, 10358075, 26600389, 28099936, 14664696, 31844113, 30413788, 17303659, 12228231, 21602511, 18593906, 11570877, 11410590, 11980723, 24525530, 20596890, 26751215, 27534430, 10358014, 30261343, 16006742, 22028912, 27010363
S75 Phosphorylation RLIMS-P 32704044
S152 Phosphorylation RLIMS-P 22393355
S153 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
T170 Phosphorylation IEDB 35494241
T182 Phosphorylation RLIMS-P 27534430
S184 Phosphorylation RLIMS-P 22393355
K210 Ubiquitination PhosphoSitePlus
S212 Phosphorylation Q13043 (STK4) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21245099, 22898666, 18394876, ...18786403, 19221179
S218 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P   UniProt 30559384, 18786403
K222 Acetylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus   UniProt 18786403
S235 Phosphorylation PhosphoSitePlus   UniProt 18786403
K245 Acetylation PhosphoSitePlus
S246 Phosphorylation P28482 (MAPK1) neXtProt 17113751
K248 Acetylation PhosphoSitePlus
S249 Phosphorylation P06493 (CDK1) , Q00535 (CDK5) , P24941 (CDK2) , P11802 (CDK4) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18356527, 25673854, 23469153, ...19549905, 22280365, 18408765, 17038621, 21969818
R251 Methylation PhosphoSitePlus
R253 Methylation PhosphoSitePlus
S256 Phosphorylation PR:P31749 (hAKT1) , Q13153 (PAK1) , Q16512 (PKN1) , P31749 (AKT1) , P31751 (AKT2) , P11309-2 (PIM1) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11237865, 23099444, 15353558, ...20357092, 10377430, 16157701, 11311120, 24886245, 30559384, 24452601, 35132380, 24556689, 22928011, 18226221, 31844113, 16203862, 18593906, 31063815, 28993609, 20685959, 24112473, 32787969, 31819175, 24843827, 21177856, 11980723, 26600389, 28099936, 21148296, 14664696, 30690883, 20596890, 18644889, 17596878, 12560069, 28981116, 16670089, 12228231, 15668399, 10358076, 11410590, 31519735, 10358075, 24525530, 25136826, 29533017, 30015961, 18319717, 27534430, 15457186, 26879559, 10358014, 16006742, 16076959, 29423932, 14727512, 27010363
S261 Phosphorylation PhosphoSitePlus
K262 Acetylation PhosphoSitePlus   UniProt 20543840
K265 Acetylation PhosphoSitePlus   UniProt 20543840
K274 Acetylation PhosphoSitePlus   UniProt 20543840
S276 Phosphorylation PhosphoSitePlus
S287 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 19664994, ...18669648, 20068231
S293 Phosphorylation PhosphoSitePlus
K294 Acetylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
T317 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 20863279, 27655845, ...26789264, 30002415, 18420577, 28713921, 35254053, 31492838, 30620550, 21540332, 29351928, 32574038, 30059200
T317 Phosphorylation IEDB 27920218
S318 O-Glycosylation PhosphoSitePlus
S318 Phosphorylation IEDB 30784271
S319 Phosphorylation PR:P31749 (hAKT1) , P11309-2 (PIM1) , Q13237 (PRKG2) , P31749 (AKT1) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11237865, 16157701, 11311120, ...30559384, 18226221, 21177856, 27602284, 28993609, 24112473, 10358075, 35191464, 22393355, 28099936, 14664696, 31844113, 28981116, 12228231, 18593906, 11410590, 11980723, 27534430, 10358014, 16006742, 26600389, 27010363
S322 Phosphorylation P48729 (CSNK1A1) , Q9HCP0 (CSNK1G1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11311120, 11980723
T323 Phosphorylation PhosphoSitePlus
S325 Phosphorylation P48729 (CSNK1A1) , P49841 (GSK3B) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11980723
S329 Phosphorylation Q9UBE8 (NLK) , Q13627 (DYRK1A) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20061393, 11311120, 11980723
T333 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
T402 Phosphorylation PhosphoSitePlus
S413 Phosphorylation P28482 (MAPK1) neXtProt 17113751
S416 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus 17113751
S418 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 17113751
K423 Acetylation UniProt 25009184
S429 Phosphorylation P28482 (MAPK1) neXtProt 17113751
S432 Phosphorylation Q16539 (MAPK14) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 19413330, 18669648, 17113751
T467 Phosphorylation PhosphoSitePlus
S470 Phosphorylation P28482 (MAPK1) , Q16539 (MAPK14) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 18669648, 17113751
T478 Phosphorylation P28482 (MAPK1) , Q16539 (MAPK14) HPRD   neXtProt   phospho.ELM 18669648, 17113751
S505 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
S509 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
S544 Phosphorylation RLIMS-P 27534430
S550 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 27655845, 20863279, ...26789264, 30002415, 18420577, 28713921, 35254053, 31492838, 30620550, 21540332, 29351928, 32574038, 30059200
T560 Phosphorylation Q16539 (MAPK14) , P28482 (MAPK1) neXtProt 17113751
S579 Phosphorylation RLIMS-P 27534430
K597 Acetylation PhosphoSitePlus
S616 Phosphorylation RLIMS-P 27534430
T647 O-Glycosylation GlyGen 23301498, 27655845, 20863279, ...26789264, 30002415, 18420577, 28713921, 35254053, 31492838, 30620550, 21540332, 29351928, 32574038, 30059200
T648 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 20863279, 27655845, ...26789264, 30002415, 18420577, 28713921, 35254053, 31492838, 30620550, 21540332, 29351928, 32574038, 30059200
T649 O-Glycosylation GlyGen 23301498, 27655845, 20863279, ...26789264, 30002415, 18420577, 28713921, 35254053, 31492838, 30620550, 21540332, 29351928, 25944660, 32574038, 30059200
T649 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   RLIMS-P 27534430, 25065674
S651 O-Glycosylation GlyGen 23301498, 27655845, 20863279, ...26789264, 30002415, 18420577, 28713921, 35254053, 31492838, 30620550, 21540332, 29351928, 32574038, 30059200
S651 Phosphorylation PhosphoSitePlus
S654 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 27655845, 20863279, ...26789264, 30002415, 18420577, 28713921, 35254053, 31492838, 30620550, 21540332, 29351928, 32574038, 30059200
Site PTM Type PTM Enzyme Score Source PMID
S249 Phosphorylation PR:P06493 (hCDK1) PRO 18356527


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000027896 (hFOXO1/Phos:2) pT24,pS256,pS319 PR:P31749 (hAKT1) PRO 10358075
PR:000047446 (hFOXO1/Phos:3) pS218 PRO
PR:000027894 (hFOXO1/iso:1/Phos:1) pS249 PR:P06493 (hCDK1) PRO 18356527


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q12778 (FOXO1) T24 Q53ET0 (CRTC2) inhibited_association eFIP 22384145


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000027894 (hFOXO1/iso:1/Phos:1) NOT Interaction PRO 18356527


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S22 W22 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
S22 T22 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S22 P22 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T24 A24 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
T24 M24 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T24 N24 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T24 I24 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S75 T75 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S75 R75 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S152 N152 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S152 T152 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S152 R152 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T182 A182 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K210 R210 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S218 F218 Biomuta DOID:4159 / skin cancer [ cosmic ]
S234 R234 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S234 N234 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S249 Y249 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R251 K251 Biomuta DOID:4159 / skin cancer [ cosmic ]
R251 S251 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
K262 E262 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K265 E265 Biomuta DOID:4159 / skin cancer [ cosmic ]
S287 N287 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S293 Y293 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T323 A323 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S329 L329 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T402 M402 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1612 / breast cancer [ cosmic ]
S432 N432 Biomuta DOID:363 / uterine cancer [ cosmic ]
T478 I478 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
T478 S478 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S505 P505 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S550 L550 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
S550 P550 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S550 W550 Biomuta DOID:1324 / lung cancer [ cosmic ]
S579 Y579 Biomuta DOID:263 / kidney cancer [ cosmic ]
S654 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]