iPTMnet Report for Q12772 (SREBF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12772 / SRBP2_HUMAN
Protein Name Sterol regulatory element-binding protein 2
Gene Name Name: SREBF2
Synonyms:BHLHD2,SREBP2;
Organism Homo sapiens (Human)

PRO ID PR:Q12772
DAG View
PRO Name sterol regulatory element-binding protein 2 (human)
Definition A sterol regulatory element-binding protein 2 that is encoded in the genome of human.
Short Label hSREBF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12772 (SREBF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S79 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
T96 O-Glycosylation GlyGen 32938750
S101 Phosphorylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
T124 Phosphorylation PhosphoSitePlus
T149 O-Glycosylation GlyGen 34019948, 31637018, 35132862, ...35254053
T153 Phosphorylation PhosphoSitePlus
T155 Phosphorylation PhosphoSitePlus
S157 O-Glycosylation GlyGen 34019948, 31637018, 35132862, ...35254053
Y171 Phosphorylation PhosphoSitePlus
K249 Sumoylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K321 Acetylation PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
K363 Acetylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
K420 Sumoylation PhosphoSitePlus
S432 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 14988395
S455 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 14988395, 18403372
K464 Sumoylation PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
K630 Acetylation PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
K731 Ubiquitination PhosphoSitePlus
S745 Phosphorylation PhosphoSitePlus
C762 Methylation IEDB 31844290
K768 Ubiquitination PhosphoSitePlus
K778 Ubiquitination PhosphoSitePlus
K782 Ubiquitination PhosphoSitePlus
K805 Ubiquitination PhosphoSitePlus
K817 Ubiquitination PhosphoSitePlus
K821 Ubiquitination PhosphoSitePlus
K823 Ubiquitination PhosphoSitePlus
Y840 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S855 Phosphorylation PhosphoSitePlus   UniProt 23186163
K865 Ubiquitination PhosphoSitePlus
C874 Methylation IEDB 31844290
K901 Ubiquitination PhosphoSitePlus
K907 Ubiquitination PhosphoSitePlus
K918 Ubiquitination PhosphoSitePlus
K934 Ubiquitination PhosphoSitePlus
K989 Ubiquitination PhosphoSitePlus
K1031 Ubiquitination PhosphoSitePlus
S1046 Phosphorylation PhosphoSitePlus
S1057 Phosphorylation PhosphoSitePlus
K1067 Ubiquitination PhosphoSitePlus
S1094 Phosphorylation PhosphoSitePlus
S1098 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1115 Ubiquitination PhosphoSitePlus
S1121 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y840 Phosphorylation HPRD 17287340


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S79 N79 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S101 F101 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y171 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K340 I340 Biomuta DOID:263 / kidney cancer [ cosmic ]
K349 E349 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K395 R395 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K395 N395 Biomuta DOID:1324 / lung cancer [ cosmic ]
K731 E731 Biomuta DOID:1324 / lung cancer [ cosmic ]
K821 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K901 T901 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1094 F1094 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1098 F1098 Biomuta DOID:4159 / skin cancer [ cosmic ]