iPTMnet Report for Q08493 (PDE4C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q08493 / PDE4C_HUMAN
Protein Name cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Gene Name Name: PDE4C
Synonyms:DPDE1;
Organism Homo sapiens (Human)

PRO ID PR:Q08493
DAG View
PRO Name cAMP-specific 3',5'-cyclic phosphodiesterase 4C (human)
Definition A cAMP-specific 3',5'-cyclic phosphodiesterase 4C that is encoded in the genome of human.
Short Label hPDE4C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q08493 (PDE4C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y47 Phosphorylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus
S119 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S124 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus
K238 Methylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
T306 Phosphorylation PhosphoSitePlus
T499 Phosphorylation PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
S641 Phosphorylation P28482 (MAPK1) PhosphoSitePlus   Signor 11030732
T646 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
Site PTM Type PTM Enzyme Score Source PMID
S487 Phosphorylation HPRD 18767875
T499 Phosphorylation HPRD 20068231
S502 Phosphorylation HPRD 20068231
T646 Phosphorylation HPRD 15302935
Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 12023945
S381 Phosphorylation HPRD 18767875
T393 Phosphorylation HPRD 20068231
S396 Phosphorylation HPRD 20068231
S535 Phosphorylation P28482 (MAPK1) PhosphoSitePlus 11030732
T540 Phosphorylation HPRD 15302935
Site PTM Type PTM Enzyme Score Source PMID
S455 Phosphorylation HPRD 18767875
T467 Phosphorylation HPRD 20068231
S470 Phosphorylation HPRD 20068231
T614 Phosphorylation HPRD 15302935


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S48 L48 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S131 L131 Biomuta DOID:1324 / lung cancer [ cosmic ]
S136 F136 Biomuta DOID:4159 / skin cancer [ cosmic ]
S234 P234 Biomuta DOID:1612 / breast cancer [ cosmic ]
S381 G381 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S455 G455 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S487 G487 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T540 I540 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T614 I614 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T646 I646 Biomuta DOID:10283 / prostate cancer [ cosmic ]