iPTMnet Report for Q07960 (ARHGAP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q07960 / RHG01_HUMAN
Protein Name Rho GTPase-activating protein 1
Gene Name Name: ARHGAP1
Synonyms:CDC42GAP,RHOGAP1;
Organism Homo sapiens (Human)

PRO ID PR:Q07960
DAG View
PRO Name Rho GTPase-activating protein 1 (human)
Definition A Rho GTPase-activating protein 1 that is encoded in the genome of human.
Short Label hARHGAP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q07960 (ARHGAP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22223895
S5 Phosphorylation HPRD   PhosphoSitePlus 18491316
T12 Phosphorylation PhosphoSitePlus
T16 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
S47 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 23186163
K48 Ubiquitination PhosphoSitePlus
S49 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 20166139, 18669648, ...20068231
S50 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 23186163
S51 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18578522, 17287340, 23186163, ...18767875, 21406692, 19651622, 18669648, 18707149, 18088087, 19415658, 20068231
K59 Ubiquitination PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus
Y65 Phosphorylation PhosphoSitePlus
K80 Acetylation PhosphoSitePlus   UniProt 19608861
K80 Ubiquitination PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
Y144 Phosphorylation PhosphoSitePlus
Y159 Phosphorylation PhosphoSitePlus
T169 Phosphorylation HPRD   PhosphoSitePlus 20068231
K212 Acetylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K218 Methylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
T220 Phosphorylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
Y365 Phosphorylation PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S50 C50 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S433 C433 Biomuta DOID:4159 / skin cancer [ cosmic ]