iPTMnet Report for Q07889 (SOS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q07889 / SOS1_HUMAN
Protein Name Son of sevenless homolog 1
Gene Name Name: SOS1
Organism Homo sapiens (Human)

PRO ID PR:Q07889
DAG View
PRO Name son of sevenless homolog 1 (human)
Definition A son of sevenless homolog 1 that is encoded in the genome of human.
Short Label hSOS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q07889 (SOS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K96 Ubiquitination PhosphoSitePlus
Y155 Phosphorylation PhosphoSitePlus
T158 Phosphorylation PhosphoSitePlus
T378 Phosphorylation PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
K413 Methylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
K420 Methylation PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
Y615 Phosphorylation PhosphoSitePlus
Y618 Phosphorylation PhosphoSitePlus
C693 Methylation IEDB 31844290
S757 Phosphorylation PhosphoSitePlus
S802 Phosphorylation PhosphoSitePlus
K811 Ubiquitination PhosphoSitePlus
S853 Phosphorylation PhosphoSitePlus
S1000 Phosphorylation PhosphoSitePlus
T1006 Phosphorylation PhosphoSitePlus
K1012 Ubiquitination PhosphoSitePlus
S1032 Phosphorylation IEDB 32387766
Y1033 Phosphorylation PhosphoSitePlus
S1043 Phosphorylation phospho.ELM   PhosphoSitePlus 12509440
S1064 Phosphorylation PhosphoSitePlus
Y1065 Phosphorylation PhosphoSitePlus
S1078 Phosphorylation PhosphoSitePlus
S1082 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 23186163, 24275569
S1132 O-Glycosylation GlyGen 31373491
S1132 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor 8816480
S1134 Phosphorylation Q15418 (RPS6KA1) phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...22827337
S1136 Phosphorylation PhosphoSitePlus
S1137 O-Glycosylation GlyGen 31373491
S1137 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1161 Phosphorylation Q15418 (RPS6KA1) PhosphoSitePlus   UniProt 22827337
S1166 Phosphorylation PhosphoSitePlus
S1167 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor 8816480
S1169 Phosphorylation PhosphoSitePlus
S1178 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8816480, 29440291, 23186163
K1190 Acetylation PhosphoSitePlus
S1193 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor 8816480
R1195 Methylation PhosphoSitePlus
Y1196 Phosphorylation PhosphoSitePlus
S1197 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus 8816480
S1210 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 23186163
T1222 Phosphorylation PhosphoSitePlus
S1229 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1252 Phosphorylation PhosphoSitePlus
T1257 Phosphorylation PhosphoSitePlus
T1263 Phosphorylation PhosphoSitePlus
S1265 Phosphorylation PhosphoSitePlus
T1269 Phosphorylation PhosphoSitePlus
S1275 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T1279 Phosphorylation PhosphoSitePlus
S1297 Phosphorylation PhosphoSitePlus
T1298 Phosphorylation PhosphoSitePlus
S1299 Phosphorylation PhosphoSitePlus
S1332 Phosphorylation PhosphoSitePlus
S1333 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1078 Phosphorylation HPRD 19413330
S1082 Phosphorylation HPRD 19413330, 15302935
S1132 Phosphorylation P28482 (MAPK1) HPRD 8816480
S1134 Phosphorylation HPRD 19651622, 18767875, 18669648
S1137 Phosphorylation HPRD 19651622, 18669648
S1167 Phosphorylation P28482 (MAPK1) HPRD 8816480
S1178 Phosphorylation P28482 (MAPK1) HPRD 8816480
S1193 Phosphorylation P28482 (MAPK1) HPRD 8816480
S1197 Phosphorylation P28482 (MAPK1) HPRD 8816480
S1210 Phosphorylation HPRD 15302935
S1275 Phosphorylation HPRD 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049322 (hSOS1/Phos:1) pS1132,pS1167,pS1178,pS1193 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T378 S378 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S401 N401 Biomuta DOID:4159 / skin cancer [ cosmic ]
K420 R420 Biomuta DOID:4362 / cervical cancer [ cosmic ]
Y615 C615 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1078 F1078 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1082 F1082 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1082 Y1082 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1134 C1134 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1136 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S1137 F1137 Biomuta DOID:4159 / skin cancer [ cosmic ]
R1195 * Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S1197 L1197 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1332 F1332 Biomuta DOID:4159 / skin cancer [ cosmic ]