iPTMnet Report for Q07820 (MCL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q07820 / MCL1_HUMAN
Protein Name Induced myeloid leukemia cell differentiation protein Mcl-1
Gene Name Name: MCL1
Synonyms:BCL2L3;
Organism Homo sapiens (Human)

PRO ID PR:Q07820
DAG View
PRO Name induced myeloid leukemia cell differentiation protein Mcl-1 (human)
Definition An induced myeloid leukemia cell differentiation protein Mcl-1 that is encoded in the genome of human.
Short Label hMCL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q07820 (MCL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Methylation PhosphoSitePlus
K5 Ubiquitination PhosphoSitePlus
K40 Acetylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
S64 Phosphorylation P45983 (MAPK8) , P24941 (CDK2) , P06493 (CDK1) neXtProt   PhosphoSitePlus   RLIMS-P 20526282, 27738316, 25733019, ...26219338, 17463001, 23024798, 27166195
T68 Phosphorylation PhosphoSitePlus
T70 Phosphorylation PhosphoSitePlus   RLIMS-P 27166195
T92 Phosphorylation P06493 (CDK1) , P27361 (MAPK3) , P24941 (CDK2) neXtProt   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor 20526282, 27738316, 18676833, ...26219338, 21368834
S121 Phosphorylation P45983 (MAPK8) , P24941 (CDK2) , P53779 (MAPK10) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 27738316, 12223490, 18669648, ...26219338, 23024798, 17670986
Y129 Phosphorylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus
T156 Phosphorylation PhosphoSitePlus
S159 Phosphorylation P49841 (GSK3B) , P49840 (GSK3A) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 27738316, 24327018, 24428916, ...16543145, 17463001, 26720004, 22751450, 35857899, 22558078, 19734538, 29435156, 24779770, 23024798, 28522751, 24261825, 25499217, 23872733
S162 Phosphorylation PhosphoSitePlus   UniProt 23024798
T163 Phosphorylation P24941 (CDK2) , P53779 (MAPK10) , P27361 (MAPK3) , P45983 (MAPK8) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 26720004, 29435156, 29291023, ...22558078, 15241487, 23872733, 19903766, 24428916, 25596730, 18220336, 25499217, 26219338, 23024798, 27738316, 12223490, 25324174, 21507240, 35151832, 18676833, 22751450, 32587776, 17670986, 30741422
K194 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
S245 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
Y347 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S121 Phosphorylation HPRD 18669648
S159 Phosphorylation P49840 (GSK3A) , P49841 (GSK3B) HPRD 16543145
T163 Phosphorylation P49840 (GSK3A) , P49841 (GSK3B) , P28482 (MAPK1) HPRD 15241487, 16543145
Y347 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S121 Phosphorylation HPRD 18669648
S159 Phosphorylation P49840 (GSK3A) , P49841 (GSK3B) HPRD 16543145
T163 Phosphorylation P28482 (MAPK1) , P49841 (GSK3B) , P49840 (GSK3A) HPRD 15241487, 16543145
K267 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q07820 (MCL1) S159 Q969H0 (FBXW7) increased_association eFIP 24261825
Phosphorylation Q07820 (MCL1) T163 Q969H0 (FBXW7) unknown eFIP 28404959
Phosphorylation Q07820 (MCL1) S159 Q9Y297 (BTRC) unknown eFIP 24261825
Phosphorylation Q13794 (PMAIP1) S13 Q07820 (MCL1) inhibited_association eFIP 26411306


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K267 N267 Biomuta DOID:1612 / breast cancer [ cosmic ]